Body weight change

Woolverton, W.L. Martin, B.R. and Balster, R.L. Modification of the behavioral effects of phencyclidine by repeated drug administration and body weight changes. Pharmacol Bi ochem Behav 12 761-766, 1980. 

The available data did not adequately identify target organs or effects. In acute lethality studies in rats gavaged with 5,000 mg/kg doses of the water-in-oil emulsion hydraulic fluids or mineral oil hydraulic fluids, no deaths or body weight changes occurred. One of these fluids was tested for neurotoxicity in chickens without effects. 

No data were located regarding toxic effects in humans following oral exposure to polyalphaolefin hydraulic fluids. No deaths or body weight changes occurred in rats in a series of acute lethality studies with nine polyalphaolefin hydraulic fluids at doses ranging from 4,250 to 5,000 mg/kg. One of these fluids was also tested for neurotoxicity in chickens, and did not produce effects at 4,250 mg/kg. The available data have not identified a target organ or effect for these fluids. The data are inadequate for MRL derivation. No intermediate or chronic oral MRLs for polyalphaolefin hydraulic fluids were derived due to the lack of data. 

Separation of dose-response curves from lethality curves Body weight changes... 

TABLE 5.8. Examples of Body Weight Changes in Rats from Minimal Acute Toxicity Studies... 

Statistical analysis is a very useful tool for evaluating the effects of treatment on many developmental and reproductive toxicity parameters. For some parameters, such as maternal body weight changes, fetal weight, and horizontal activity in an open field, the comparison to the concurrent control is the primary consideration and, assuming adequate group size, the investigator relies heavily on the results of appropriate statistical analyses to interpret differences from control. 

Other Systemic Effects. Adrenal fibrosis with lipid accumulation was reported in one study in mice, but these effects have not been observed in humans known to be exposed to heptachlor and have not been verified in other species. There has been no measurement of adrenal hormone in exposed humans or animals. Body weight changes have, in general, been accompanied by a decrease in food consumption, due possibly to taste aversion. 

The mice in the 16-day study did not have decreased growth. Body weight changes were not consistent or dose-related in the rats or mice treated with up to 1000 mg/kg/day in the 13- week experiment or up to 500 mg/kg/day in the 103-week experiment (NTP 1986). Male rats treated with... 

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