Nicotine analogs

Cronan T, Conrad 1, Bryson R (1985) Effects of chronically administered nicotine and saline on motor activity in rats. Pharmacol Biochem Behav 22 897-899 Damaj MI, Glassco W, Marks Ml, Slobe B, James JR, May EL, Rosecrans JA, Collins AC, Martin BR (1997) Pharmacological investigation of (-F)- and (—)-c. s-2,3,3a,4,5,9b-hexahydro-l-methyl-l/7-pyrrolo-[3,2-/ ]isoquinoline, a bridged-nicotine analog, J Pharmacol Exp Ther 282 1425-1434... 

A racemic nicotine analog, fra s-3-hydroxymethyl-nicotine, was converted to the hemisuccinate, which was conjugated to protein to form an immunogen (Fig. 4 [8c]). The resulting antiserum was used with tiitiated 1-nicotine as radioligand. With this radioligand the assay was highly selective for 1-nicotine, with less than 0,01% cross-reaction with d-nicotine. Similar enantioselectivity is claimed for 1-cotinine (42). 

The findings that S-nicotine ameliorates some of the symptoms of the Alzheimer syndrome (110) and has a neuroprotective effect in animals (11 l)have stimulated increased interest in nicotine analogs and congeners. Members of a series of 3 -, 4 -, and 5 -substi-tuted nicotine analogs (64) were evaluated as... 

Nicotine Derivatives. A large number of nicotine analogs have been reported, and the SAR of nicotine derivatives has been presented in a recent review by Tonder et al. (295). Described herein are two classes of nicotine derivatives 5-substituted nicotine analogs (e.g., SIB-1508Y, 51)and pyrrolidine ring-opened nicotinoids (e.g., RJR-2403,57). 

Cholinergic receptor agonists Muscarinic receptors Benzyl quinolone carboxylic acid analogs Cevimeline EUK1001 Lanomeline Vedaclidine Nicotinic receptors Nicotinic analog ZY-1... 

Glennon, R.A., Dukat, M., 1999b. Nicotine analogs structure-affinity relationships for central acetyl-cholinergic receptor binding. In Yamamoto, I., Casida, J.E. (Eds.), Nicotinoid Insecticides and the Nicotinic Acetylcholine Receptor. Spinger-Verlag, Tokyo, 237-252. 

Lin, N.-H., Carrera, G.M., Anderson, D.J., 1994. Synthesis and evaluation of nicotine analogs as neuronal nicotinic acetylcholine receptor ligands. J. Med. Chem. 37, 3542-3553. 

CD-bonded stationary phases are suitable for the separation of positional, geometric and optical isomers, derivatives of dansyl racemic amino acids, analogues of nicotine and nicotine analogs, arbitrates and derivatives of benzodiazepin as well as organic nitrates, imidazol derivatives, etc. Table 8.2 shows that some enantioselective stationary phases are based on modified CDs [32,33]. The first CD derivatives used as a chiral stationary phase in HPLC were hydroxypropyl, acetylated and carbamoylated /3-CD, which demonstrated better selectivity behaviors than native /3-CD. The most common commercial species of CD derivatives include water-soluble methylated CD (2,6-di-0-methyl-j8-CD) and HP-j6-CD, then acetylated CD, carboxymethylated CD, naphthyl ethyl carbamate-j8-CD,... 

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