Pharmacogenetics genetics

Key words Antipsychotics, Pharmacogenetics, Genetics, Schizophrenia, Response, Side effects... 

Neelam, C., Shubha, R., and Padh, H., Pharmacogenetics Genetic basis for rational drug therapy. Review, Indian J. Pharm. Sci., 69, 180, 2007. 

Essential to the definition of Pharmacogenetics is the term genetic polymorphism. It is extrapolated that there are at least three million genetic polymorphisms in the human genome. Historically, a genetic polymorphism was defined as a genetic variation with a population frequency of 1% and above, but the larger inter-ethnic variation of population frequencies makes a strict definition based on such frequencies impractical. The most common molecular type of polymorphism is the... 

Pharmacogenetics. Table 1 Selected genetic polymorphisms and their medical impact... 

Lambert CG. Compound-selection pharmacogenetics tools. Genet Eng News 2003 23(l) 30-2. 

As indicated above, pharmacogenetics is the study of the roles of genetic variations in the responses to drugs. As a result of the progress made in sequencing the... 

Dahl, M. L., Yue, Q. Y. etal. (1995). Genetic analysis oftheCYP2D locus in relation to debriso-quine hydroxylation capacity in Korean, fapanese and Chinese subjects. Pharmacogenetics, 5(3), 159-64. 

Serretti, A. Smeraldi, E. (2004). Neural network analysis in pharmacogenetics of mood disorders. BMC Med. Genet., 5(1), 27. 

Kreek, M.J., Bart, G., Lilly, C., LaForge, K.S., and Nielsen, D.A., Pharmacogenetic and human molecular genetics of opiate and cocaine addictions and their treatments, Pharmacol. Rev., 57, 1, 2005. 

Pharmacogenetics The study of the genetic determinants of drug metabolism. 

Observations of person-to-person differences in the metabolism of drugs and consequently in drug kinetics and response led to the concepts of pharmacogenetics. The same principal concepts apply to the genetic variability in the reaction to food components (e.g., lactose intolerance) or to environmental toxins (e.g., carcinogens). These fields often are termed ecogenetics and toxicogenetics . 

Drazen JM, Yandava CN, Dube L, SzCZERBACK N, HlPPENSTEEL R, PlLLARI A et al. Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment. Nature Genet 1999 22[2] 168-170. 

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