Genetic studies Pharmacogenetics

These examples comprise only a small part of the molecular genetic studies that have been conducted on pharmacogenetic polymorphisms, They afford insights... 

These methodological differences account, at least in part, for the lack of replication observed across pharmacogenetic studies of antipsychotic response. Despite the challenges of conducting genetic studies in this area, a number of variants have shown consistent association with antipsychotic metabolism and response (Table 3). 

Nevertheless, the debate on the biological basis of race and ethnicity and pharmacogenetics may provide a useful understanding of ethnic and racial differences. Even in this case, however, we should not ignore several important parameters such as diet, economic, environmental, and psychosocial factors. However, pharmaco-genetic studies on race and ethnicity are worthwhile because they are useful indicators of genetic variation. However, this kind of race and ethnicity classification for medical treatment could lead to discrimination [122]. 

Kraus S, Hummler S, Toriola AT, Poole EM, Scherer D, Kotzmann J, et al. Impact of genetic polymorphisms on adenoma recurrence and toxicity in a COX2 inhibitor (celecoxib) trial results from a pilot study. Pharmacogenet Genomics August 2013 23(8) 428-37. 

As indicated above, pharmacogenetics is the study of the roles of genetic variations in the responses to drugs. As a result of the progress made in sequencing the... 

Pharmacogenetics The study of the genetic determinants of drug metabolism. 

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