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Clinical pharmacogenetics genetic polymorphisms

Eichelbaum M, Gross AS. The genetic polymorphism of debrisoquine/ sparteine metabolism—clinical aspects. In Kalow W, ed. Pharmacogenetics of drug metabolism. New York Pergamon Press Inc, 1992 625-648. [Pg.66]

Bhasker CR, McKinnon W, Stone A, Lo AC, Kubota T, Ishizaki T, Miners JO (2000) Genetic polymorphism of UDP-glucuronosyltransferase 2B7 (UGT2B7) at amino acid 268 ethnic diversity of alleles and potential clinical significance. Pharmacogenetics 10 679-685... [Pg.141]

Krynetski EY, Tai HE, Yates CR, Eessing MY, Loennechen T, Schuetz JD et al. Genetic polymorphism of thiopurine S-methyltransferase Clinical importance and molecular mechanisms. Pharmacogenetics 1996 6 279-90. [Pg.194]

Based on the individual variability in the behaviour of the liver cell towards foreign substances and drugs, the thesis was put forward that both the effectiveness as well as the side-effects of medicaments are genetically determined (A.G. Motulsky, 1957). As a result, the term pharmacogenetics (F. Vogel, 1959) was introduced to define clinically relevant, hereditary differences in the effects of drugs which lead to abnormal reactions in patients (due to genetic polymorphism). (17, 22, 99, 103)... [Pg.52]

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Clinical genetics

Clinical pharmacogenetics

Clinical pharmacogenetics polymorphism

Genetics polymorphism

Pharmacogenetic

Pharmacogenetics

Pharmacogenetics genetics

Pharmacogenetics polymorphisms

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