Pharmaceutical products chemical deterioration

Chemical and physico-chemical deterioration of pharmaceutical products... 

Medical or pharmaceutical products are spoiled if they contain pathogens or opportunistic pathogens, if they contain toxic microbial metabolites, or if microbial growth has caused physical or chemical deterioration of the product. It should be realised that an organism that is harmless to a person in good health... 

An inherent problem in the usage of phenolic lipids, particularly in surface coatings, is the discolouration which can impair products. Apart from colourants arising from the solvent action of CNSL on the shell in the industrial process, the dihydric phenols In CNSL notably the minor component 2-methylcardol (ref. 200) more than cardol appear to be the cause of this deterioration rather than the monohydric member, cardanol. The usage of purer cardanol, or the less unsaturated material by semi-hydrogenation or chemical reduction, as well as the Incorporation of an antioxidant are methods for colour stabilisation (ref. 277). Antioxidant applications and pharmaceutical uses of CNSL and its component phenols are referred to in the next section. 

In the manifold types of production processes in industry, waters of very different properties are required, depending on the type of plants and on the technological processes. For example, the foodstuff industry requires hy-gienically safe water, production of pharmaceuticals and fine chemicals requires distilled water, for other industries (metallurgical, engineering, etc.) simply treated or even untreated surface water is sufficient. Unsuitable quality of industrial water can cause a deterioration in the quality of products, reduced production capacity and equipment corrosion. Except for some specific requirements for the quality of water for the different industrial sectors, some requirements are common to the majority of operations [1-8] ... 

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