Pharmaceutical analysis mass spectrometric detection

Ayrton J. et al., 1998. Optimisation and routine use of generic ultra-high flow-rate liquid chromatography with mass spectrometric detection for the direct online analysis of pharmaceuticals in plasma. J Chromatogr A 8282 199. 

Beider, D., and Stijckigt, D. (1996). Analysis of basic pharmaceuticals by capillary electrophoresis in coated capillaries and on-line mass spectrometric detection.. Chromatogr. A 752, 271—277. 

Ayrton, J. Clare, R.A. Dear, G.J. Mallett, D.N. Plumb, R.S. Ultra-High Flow Rate Capillary Liquid Chromatography with Mass Spectrometric Detection for the Direct Analysis of Pharmaceuticals in Plasma at Sub-Nanogram per Milliliter Concentrations, Rapid Commun. Mass Spectrom. 13, 1657-1662 (1999). 

Speciation of organometallic compounds containing Au and Ag, on the other hand, was paid only scant attention as a subject for analytical research. The analytical methods that supported research on these compounds had to be dug out from the experimental sections of articles dealing with diverse aspects of chemistry, physics, biochemistry, etc. A review appeared on some of the antiinflammatory drugs shown in Table 1, discussing determination of Au in body fluids and pharmaceutical preparations, and speciation of the compounds and their metabolites. The methods included varieties of atomic absorption spectroscopy (AAS), varieties of neutron activation analysis (NAA), inductively coupled plasma spectrometry combined with mass spectrometric detection (ICP-MS),... 

Chiral CE using mass spectrometric detection has also been utilized for detailed qualitative analysis of pharmaceuticals, a review by Shamsi [115] covers the various modes of CE-MS including the use of neutral CDs for FSCE-MS and MEKC-MS. 

Faniewski, K., Wannman, T., Hagman, G. Gas chromatography with mass spectrometric, atomic emission and Fourier transform infrared spectroscopic detection as complementary analytical techniques for the identification of unknown impurities in pharmaceutical analysis. J. Chromatogr. A 985, 275-282 (2003)... 

This chapter provides an overview of the analysis of TPs in the environment of three important classes of synthetic chemicals namely pesticides, human and veterinary pharmaceuticals, and personal care products (PPCPs). A series of analytical protocols applied to determine and analyze TPs of manmade chemicals originating from photolysis as well as from microbial degradation in the environment and wastewater treatment plants (WWTPs) is presented. Furthermore, strategies for identifying unknown TPs of xenobi-otic compounds including pesticides and PPCPs are presented based on the combination of mass spectrometric techniques and NMR, IR, and optical detection systems like DAD and FL. 

In environmental analysis, there has been increasing use of TOF, quadrupole. ion-trap, and Fourier transform mass spectrometers in addition to desorption ionization methods such as MALDI. Detection and quantitative determination of such widely diverse contaminants as perfluoroorganics, polybromi-nated diphenyl ethers, pharmaceuticals, byproducts of water disinfection, pesticides, algal toxins, surfactants, methyl-t-butyl ether, arsenic, and various microorgan-i.sms are now carried out using mass spectrometric methods. Mass spectrometry is also used to determine compounds of interest in homeland security. ... 

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