Phage Effect

The overall effect of bacteriophage contaminations is influenced by several factors related to the characteristics of the phage itself as well as the timing of infection relative to the stage of the fermentation process. Consequently, independent infections even with the same phage can result in different outcomes. Thus, minor contaminations can only result in extended fermentation times and decreased solvent yield, whereas more severe infections can lead to complete cessation of the fermentation and/or nearly complete cell lysis within hours. 

Bacteriophages with a short latent period and large burst size tend to have the most serious consequences for the fermentation process. Such characteristics 

An infection with bacteriophages in large-scale fermentations resulted in most cases in the abandonment of the fermentation process. The ensuing cleanup operations necessitated the complete shutdown of the fermentation plant. The operators were therefore confronted with the considerable expenses associated with production losses and the additional costs incurred in removing the phages from the process equipment and environment. 

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Summarizing the data Tsulukidze [28] indicated that no side effects were observed with the topical application of phages, however if phage preparations were injected into the infected site a pain could emerge and continue over the next 1-2 hours. This pain could be explained by the tissue pressure developing after... 

Phage preparations have also been found to be very useful in the disinfection of surfaces and facilities in hospitals. Walls in wards, different surfaces, and even instruments and wounds (the source of some pathogens) have also been treated, with a considerable effect in children s clinics [41], Recent studies demonstrated a high eradicating effect of P. aeruginosa and S. aureus phages in a laboratory environmental model [42, 43]. 

Ruchko I (1936) Therapeutic effect of Staphylococcus phage for oral and dental infections. Sovetskaya Stomatologia (Russian Soviet Stomatology ) 1 11-20... 

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