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PH-responsive nanocarriers

A. Pourjavadi, S.H. Hosseini, M. Alizadeh, and C. Bennett, Magnetic pH-responsive nanocarrier with long spacer length and high colloidal stability for controlled delivery of doxorubicin, Colloids SurfB Biointerfaces, 116C, 49-54,2013. [Pg.338]

Smart polymeric carriers for drug delivery pH-responsive nanocarriers... [Pg.329]

Manchun, S., Dass, C. R. and Sriamornsak, P. (2012) Targeted therapy for cancer using pH-responsive nanocarrier systems. Life Sci, 90,381-387. [Pg.353]

Dehousse V, Garbacki N, Colige A et al (2010) Development of pH-responsive nanocarriers using trimethylchitosans and methacrylic acid copolymer for siRNA delivery. Biomaterials 31 1839-1849... [Pg.21]

Fig. 3.3 Schematic illustration of pH-responsive nanocarriers targeting. pH-responsive nanocarriers accumulate in the tumor tissue via the enhanced penneabUity and retention effect through the leaky blood vessels. After pH-responsive nanocarriers accumulate in the tissue, the system is triggered to release the anticancer drug in response to extracellular pH stimuli, or is taken up by cancer cells after binding to target antigens on the surface of the cancer cells. In this latter case the drugs are released inside the cancer cells by intracellular pH stimuh. Reprinted from Manchun, S., Dass, C.R., Sriamomsak, R, 2012. Targeted therapy for cancer using pH-responsive nanocarrier systems. Life Sci. 90 (11-12), 381-387, Copyright (2012) with permission from Elsevier. Fig. 3.3 Schematic illustration of pH-responsive nanocarriers targeting. pH-responsive nanocarriers accumulate in the tumor tissue via the enhanced penneabUity and retention effect through the leaky blood vessels. After pH-responsive nanocarriers accumulate in the tissue, the system is triggered to release the anticancer drug in response to extracellular pH stimuli, or is taken up by cancer cells after binding to target antigens on the surface of the cancer cells. In this latter case the drugs are released inside the cancer cells by intracellular pH stimuh. Reprinted from Manchun, S., Dass, C.R., Sriamomsak, R, 2012. Targeted therapy for cancer using pH-responsive nanocarrier systems. Life Sci. 90 (11-12), 381-387, Copyright (2012) with permission from Elsevier.
Sawant, R. M., Hurley, J. P., Salmaso, S., Kale, A., Tolcheva, E., Levchenko, T. S., and Torchilin, V. P. (2006), SMART drug delivery systems Double-targeted pH-responsive. Pharmaceutical nanocarriers, Bioconjugate Chem., 17, 943-949. [Pg.516]

Sawant RM, Hurley JP, Saknaso S, Kale AA, Tolcheva E, Levchenko T, TorchUin VP (2006) Smart drug delivery systems double-targeted pH-responsive pharmaceutical nanocarriers. Bioconjugate Chem 17 943-949... [Pg.241]

In most cases, the as-obtained nanocarriers can release the loaded biomolecules in response to only one kind of external stimulus, such as light, pH, or temperature, and realize a monoresponsive nanochannel. However, the sensitivity of these nanocarriers is not very efficient. Even for NIR-triggered phototherapy, the effective penetration depth of NIR light is still limited to no more than 1 cm and its sensitivity and accuracy to treat tumors located deep inside the body is thus limited. Therefore, delivery systems triggered by at least two different inputs have recently been considered by researchers. Generally, in order to get dual-responsive nanocarriers, two kinds of smart materials or one material with two functional groups must be included in the same NP. For example, two kinds of responsive materials, such as PAA and PNIPAm, can be simultaneously employed in the a pH- and... [Pg.277]

Aryal S, Grailer JJ, Pilla S, Steeber DA, Gong SQ (2009) Doxorubicin conjugated GNPs as water-soluble and pH-responsive anticancer drug nanocarriers. J Mater Chem 19 7879-7884... [Pg.42]

Xu, S., Luo, Y., Graeser, R. et al. 2010. Development of pH-responsive core-shell nanocarriers for delivery of therapeutic and diagnostic agents. BioorgMed Chem Lett 198 73. [Pg.389]

Responsive polymer-coated mesoporous silica as a pH-sensitive nanocarrier for controlled release. Langmuir, 27 (6), 3095-3099. [Pg.1336]

Guo, M., Que, C., Wang, C., Liu, X., Yan, H., Liu, K., 2011. Multifunctional supeiparamagnetic nanocarriers with folate-mediated and pH-responsive targeting properties for anticancer drug delivery. Biomaterials 32 (1), 185-194. [Pg.92]

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