Reproductive toxicity pesticides

Another section of the EPA, the Office of Prevention, Pesticides, and Toxic Substances (OPPT), has recently updated and harmonized its testing guidelines for evaluating the developmental and reproductive effects of pesticides and industrial chemicals to include an assessment of endocrine disrupting properties. These guidelines will be used in future testing of pesticides under both the Toxic Substances Control Act (TSCA) and the Federal Insecticide, Fungicide and Rodenticide Act (FIFRA). 

Garcia-Reyero, N. and Denslow, N.D. (2006). Applications of genomic technologies to the study of organochlorine pesticide-induced reproductive toxicity in fish. Journal of Pesticide Science 31, 252-262. 

OECD. 2004d. Draft guidance document on reproductive toxicity testing and assessment. OECD Series on Testing and Assessment No. 43. Environment Directorate, Joint Meeting of the Chemicals Committee and the Working Party on Chemicals, Pesticides and Biotechnology. November 10, 2004 (1st version). Paris OECD. 

Nonclinical Reproductive Toxicity Testing Requirements for Drugs, Pesticides, and industriai Chemicais in india and China... 

Key words OECD guidelines, Reproductive toxicity. Chemicals, Pesticides... 

US EPA (Environmental Protection Agency), OPPTS (Office of Prevention, Pesticides and Toxic Substances). (1998) Health effects test guidelines. OPPTS 870.3800. Reproduction and fertility effects... 

The basic material a regulator uses in reproductive toxicity risk assessment for pesticides is provided in the study reports submitted by the applicant. This includes ADME studies, acute toxicity. 

Considerations for the acceptability of the are similar to those for the uncertainty factor used to calculate the RfD, RfC or other reference values from the NOAEL or BMD. The has been calculated from reproductive toxicity data for several chemicals. Examples include dinoseb (US EPA, 1986), lithium (Moore, 1995) and boric acid and borax (Moore, 1997). In the case of dinoseb, the MOEs were very low, in some cases less than one, indicating toxicity in the animal studies at levels to which people are exposed. This information on dinoseb led to an emergency suspension of use of this pesticide in the USA in 1986 and ultimately led to its removal from the market (Kimmel Kimmel, 1994,1996). 

MIC is used in industry as a chemical intermediate in the manufacture of polyurethane foams, plastics, adhesives, coating materials, pesticides, and paints.30 Humans exposed to MIC developed cardiovascular toxicity, genotoxicity, reproductive toxicity, and biochemical changes.31-34... 

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