Pesticides environmental fate data requirements

Harmonization of Environmental Chemistry and Fate Data Requirements Under NAFTA, Regulatory Proposal PRO 2001-02, Health Canada, Pesticide Regulatory Management Agency. Also available on the World Wide Web http //www.hc-sc.gc.ca/pmra-arla/english/pdf/pro/pro2001-02-e.pdf. 

Brassinosteroids, therefore, would qualify for classification as biochemical pesticides. Once they are classified as biochemical pesticides, the data requirements for U.S. registration would be significantly reduced (because of a tier approach), especially in the areas of toxicology, ecology and wildlife, and environmental fate. Because of their low use volume, brassinosteroids are unlikely to leave any residues in crops, and they would qualify for exemption from the requirement of a tolerance. If that were the case, what applicants seeking U.S. registrations need to do is to develop data on product chemistry and acute toxicology, as well as use profiles for their products, which will be dealt with on a case-by-case basis. 

The potential environmental impacts of transformation products are recognised by many regulatory assessment schemes. For example, in the EU, pesticide producers are not only required to assess the fate and effects of the parent pesticide but are also required to assess the potential adverse effects of major metabohtes and minor metabohtes that are deemed to be of concern [4]. Similar requirements also exist for new human and veterinary pharmaceuticals and biocides (e.g. [5]). However, for many older substances and many other substance classes (e.g. industrial chemicals), data on the environmental risks of transformation products can be hmited or non-existent. 

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