Peroxisome proliferation perfluorooctanoic acid

Several studies have suggested that some critical adverse effects like peroxisome proliferation, hepatotoxicity, immunotoxicity, and developmental toxicity may be associated with chemical exposure to PFCs, particularly to PFOS (perfluorooctane sulfonate) and PFOA (perfluorooctanoic acid), two ubiquitous persistent organic pollutants with possible environmental and human health risks. [Pg.183]

Abdellatif AG, Preat V, Taper HS, Roberfroid M (1991) The modulation of rat liver carcinogenesis by perfluorooctanoic acid, a peroxisome proliferator. Toxicol Appl Pharmacol 111(3) 530-537... [Pg.204]

Sohlenius, A. K., Lundgren, B., Depierre, J. W. Perfluorooctanoic acids has persistent effects on peroxisome proliferation and related paramets in mouse liver. J. Biochem. Toxicol, 7 205-212... [Pg.59]

Kudo, N., Iwase, Y., Okayachi, H., Yamakawa, Y, Kawashima, Y. Induction of hepatic peroxisome proliferation by 8-2 telomer alcohol feeding in mice formation of perfluorooctanoic acid in the liver. Toxicol. Set, 86 231-238 (2005). [Pg.60]

Abdellatif, A. G., Preat, V., Vamecq, J., Nilsson, R., and Roberfroid, M. (1990). Peroxisome proliferation and modulation of rat liver carcinogenesis by 2,4-dichlorophenoxyacetic acid, 2,4,5-trichlorophenoxy-acetic acid, perfluorooctanoic acid and nafenopin. Carcinogenesis 11, 1899-1902. [Pg.467]

Abbott BD, Wolf CJ, Schmid JE et al (2007) Perfluorooctanoic acid-induced developmental toxicity in the mouse is dependent on expression of peroxisome proliferator-activated receptor-alpha. Toxicol Sci 98(2) 571-581... [Pg.194]

Abbott BD, Wood CR, Watkins AM et al (2012) Effects of perfluorooctanoic acid (PFOA) on expression of peroxisome proliferator-activated receptors (PPAR) and nuclear receptor-regulated genes in fetal and postnatal CD-I mouse tissues. Reprod Toxicol 33(4) 491-505 Andersen CS, Fei CY, Gamborg M et al (2010) Prenatal exposures to perfluorinated chemicals and anthropometric measures in infancy. Am J Epidemiol 172(11) 1230-1237 Apelberg B J, Witter ER, Herbstman JB et al (2007) Cord serum concentrations of perfluorooctane sulfonate (PEGS) and perfluorooctanoate (PEOA) in relation to weight and size at birth. Environ Health Perspect 115(11) 1670-1676... [Pg.195]

Kim S, Choi K, Ji K et al (2011) Trans-placental transfer of thirteen perfluorinated compounds and relations with fetal thyroid hormones. Environ Sci Technol 45(17) 7465-7472 Klaunig J, Hocevar B, Kamendulis L (2012) Mode of action of perfluorooctanoic acid (PFOA) tumorigenicity and human relevance. Reprod Toxicol 33(4) 410-418 Kudo N, Iwase Y, Okayachi H et al (2005) Induction of hepatic peroxisome proliferation by 8-2 telomer alcohol feeding in mice Formation of perfluorooctanoic acid in the liver. Toxicol Sci 86(2) 231-238... [Pg.199]

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