Peripheral ulcer

Messmer EM, Foster CS.Vasculitic peripheral ulcerative keratitis. Surv Ophthalmol 1999 43 379-396. 

Infiltrative events includes six subcategories microbial keratitis, CL-induced peripheral ulcer, CL-induced red eye, infiltrative keratitis, asymptomatic infiltrative keratitis, and asymptomatic infiltration... 

Aasuri MK,Venata N, Kumar VM. Differential diagnosis of microbial keratitis and contact lens-induced peripheral ulcer. Eye Contact Lens 2003 29(1 suppl) S60-S62 discussion S83-S84, SI92-SI94. 

Many patients with advanced peripheral arterial disease are more limited by the consequences of peripheral ischemia than by myocardial ischemia. In the cerebral circulation, arterial disease may be manifest as stroke or transient ischemic attacks. The painful symptoms of peripheral arterial disease in the lower extremities (claudication) typically are provoked by exertion, with increases in skeletal muscle O2 demand exceeding blood flow impaired by proximal stenoses. When flow to the extremities becomes critically limiting, peripheral ulcers and rest pain from tissue ischemia can become debilitating. 

The peripherally acting antiadrenergic drugs are contraindicated in patients with a hypersensitivity to any of the drugs. Reserpine is contraindicated in patients who have an active peptic ulcer or ulcerative colitis and in... 

A topical enzyme aids in the removal of dead soft tissues by hastening the reduction of proteins into simpler substances. This is called proteolysis or a proteolytic action. The components of certain types of wounds, namely necrotic (dead) tissues and purulent exudates (pus-containing fluid), prevent proper wound healing. Removal of this type of debris by application of a topical enzyme aids in healing. Examples of conditions that may respond to application of a topical enzyme include second- and third-degree bums, pressure ulcers, and ulcers caused by peripheral vascular disease An example of a topical enzyme is collagenase (Santyl). 

Taxanes Fhclitaxel Neutropenia, peripheral neuropathy Alopecia, fluid retention, myalgia, skin reactions, ulceration necrosis with extravasation, bradycardia, stomatitis, hypersensitivity reactions... 

Pitcher MCL, Beatty ER, Harris RM, et al. 1998. Sulfur metabolism in ulcerative colitis investigation of detoxification enzymes in peripheral blood. Dig Dis Sci 43 2080-2085. 

The answer is c. (Katzung, p 835J Dideoxycytidine causes dose-dependent peripheral neuropathies and adverse effects in the GI tract, including nausea, diarrhea, and gastric and esophageal ulcerations and pancreatitis... 

Therapeutic applications. PG derivatives are used to induce labor or to interrupt gestation (p. 126) in the therapy of peptic ulcer (p. 168). and in peripheral arterial disease. 

A study of 204 workers exposed for from 1 month to 20 years to 2,4,5-T and its contaminants (concentrations unspecified) showed no evidence of increased risk for cardiovascular disease, hepatic disease, renal damage, central or peripheral nervous system effects, reproductive problems, or birth defects. Clinical evidence of chloracne persisted in 55.7%, and an association between exposure and history of upper gastrointestinal tract ulcer was found. 

Phentolamine is used for peripheral blood circulation disorders, in particnlar in the beginning stages of gangrene, for treatment of trophic ulcers of the extremities, bedsores, and frostbite. Synonyms of this drug are regitine and dibazin. 

Combination therapy - For toxicities likely to be associated with zalcitabine (eg, peripheral neuropathy, severe oral ulcers, pancreatitis, elevated liver function tests, especially in patients with chronic hepatitis B see Warnings and Precautions), interrupt or reduce dose. For severe toxicities or those persisting after dose reduction, interrupt zalcitabine therapy. For recipients of combination therapy with zalcitabine and other antiretrovirals, base dose adjustments or interruption for either drug on the known toxicity profile of the individual drugs. 

The following adverse events were reported in at least 3% of all patients Infection headache rhinitis nausea dizziness pharyngitis cough asthenia abdominal pain rash respiratory disorder dyspepsia sinusitis vomiting peripheral edema mouth ulcer alopecia injection site reaction. 

Aluminum Hydroxide + Magnesium Hydroxide (Maalox) [OTC] [Antacid/Aluminum Magnesium Salts] Uses Hyper-acidity (peptic ulcer, hiatal hernia, etc) Action Neutralizes gastric acid Dose Adults. 10-20 mL or 2-4 tabs PO qid or PRN Feds. 5-15 mL PO qid or PRN Caution [C, ] Disp Tabs, susp SE May cause t Mg in renal insuff, constipation, D Interactions In addition to AlOH, X effects OF digoxin, quinolones, phenytoin, Fe supl, ketoconazole EMS None OD May cause constipation, loss of appetite, painful urination, heart rhythm changes, muscle weakness, and peripheral edema symptomatic and supportive... 

Certain forms of dwarfism, type II diabetes, kidney disease, growth hormone insensitivity, cachexia, amyotrophic lateral sclerosis, peripheral neuropathy Wound healing, skin ulcers Diabetic ulcers, wound healing... 

Osteoporosis Peptic ulcer disease Peripheral vascular disease Prostatism Unsteady gait... 

---