Receptor heterogeneity

Kenakin, T. P., and Boselli, C. (1989). Pharmacologic discrimination between receptor heterogeneity and allosteric interaction Resultant analysis of gallamine and pirenzeipine antagonism of muscarinic responses in rat trachea. J. Pharmacol. Exp. Ther. 250 944—952. 

Fritschy J-M, Mohler H (1995) GABAA-receptor heterogeneity in the adult rat brain differential regional and cellular distribution of seven major subunits. J Comp Neurol 14 154-94... 

The different subtypes of levamisole receptor (receptor heterogeneity) were illustrated by the presence, in some patches, of channels with different conductances (Fig. 21.9). The different conductances were seen as channel currents opening to different levels producing different peaks in the scatter... 

Chung GG, Zerkowski MP, Ghosh S, et al. Quantitative analysis of estrogen receptor heterogeneity in breast cancer. Lab. Invest. 2007 87 662-669. 

Yallampalli, C., Chauhan, M., Thota, C.S., Kondapaka, S., and Wimalawansa, SJ. 2002. Calcitonin gene-related peptide in pregnancy and its emerging receptor heterogeneity. Trends in Endocrinology and Metabolism 13(6), 263-269. 

Genetic regulation via splice variants and RNA editing further increases receptor heterogeneity the flip/flop versions and the Q/R site 279... 

Genetic regulation via splice variants and RNA editing further increases receptor heterogeneity the flip/flop versions and the Q/R site. Splice variants that impart functional differences and/or different cellular expression patterns have been found for most of the glutamate receptor subunits. The first splice variants to be described were the so-called flip and flop versions of the AMPA... 

Watson DG, Watterson JM, Lenox RH. Sodium valproate down-regulates the myristoylated alanine-rich C kinase substrate [MARCKS) in immortalized hippocampal cells a property unique to PKC-mediated mood stabilization J Pharmacol Exp Ther 285 307-316, 1998 Watson M, Roeske WR, Yamamura HI Cholinergic receptor heterogeneity, in Psychopharmacology The Third Generation of Progress. Edited by Meltzer HY. New York, Raven, 1987, pp 241-248... 

Fang, L., Knapp, R.J., Horvath, R., Matsunaga, T. O., Haaseth, R. C., Hruby, V. J., Porreca, F., Yamamura, H. I. Characterization of fl-IJnaltrindole binding to delta opioid receptors in mouse brain and mouse vas deferens Evidence for delta opioid receptor heterogeneity, J. Pharmacol. Exp. Ther. 1994, 268, 836-846. 

Schlicker E, Kathmann M, Bitschnau H, Marr I, Reidemeister S, Stark H, Schunack W (1996) Potencies of antagonists chemically related to iodoproxyfan at histamine H3 receptors in mouse brain cortex and guinea-pig ileum evidence for H3 receptor heterogeneity Naunyn-Schmiedeberg s Arch Pharmacol 353 482-488. 

Leurs R, Kathmann M, Vollinga RC, Menge WMPB, Schlicker E, Timmerman H (1996) Histamine homologues discriminating between two functional H3 receptor assays. Evidence for H3 receptor heterogeneity. J Pharmacol Exp Ther 276 1009-1015. 

Schworer H, Reimann A, Ramadori G, Racke K (1994) Characterization of histamine H3 receptors inhibiting 5-HT release from porcine enterochromaffin cells further evidence for H3 receptor heterogeneity. Naunyn-Schmiedeberg s Arch... 

Still additional studies are necessary to solve the nature of H3 receptor heterogeneity. Cloning of the H3 receptor and potential subtype will be of great value, especially from a therapeutic point of view. 

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