Peptide drugs designer

J. L. Fauchere, C. Thurieau, Evaluation of the Stability of Peptides and Pseudopeptides as a Tool in Peptide Drug Design , in Advances in Drug Research , Vol. 23, Ed. B. Testa, Academic Press, London, 1992, p. 127- 159. 

Furthermore, we believe that our hypothesis regarding design of antagonist analogs with prolonged activity offers a potentially useful approach to peptide drug design. 

Evaluation of the stability of peptides and pseudopeptides as a tool in peptide drug design, 23, 127... 

Some aspects of amino-acid and peptide drug design... 

Yee, S. and G. L. Amidon. Oral absorption of angiotensin-converting enzyme inhibitors and peptide prodrugs. In Peptide-based Drug Design. G. L. Amidon (ed), American Chemistry Society, Washington DC 1995, 137-147. 

Kompella, U.B. and Lee, V.H.L. 2001. Delivery systems for penetration enhancement of peptide and protein drugs design considerations. Advanced Drug Delivery Reviews 46, 211-245. 

W. Wang, J. Jiang, C. E. Ballard, B. Wang, Prodrug Approaches to the Improved Delivery of Peptide Drugs , Curr. Pharm. Design 1999, 5, 265 - 287. 

The drug in this case, a siRNA, was coupled to the RVG peptide and successfully delivered to the neurons in mice. This work opens up the possibility of using the RVG as delivery tools for drugs designed for interaction with brain neurons. 

Many large proteins exert biological activity of pharmaceutical interest. In the drug design process the biological activity is often associated with an interaction mediated by certain residues or domains. Peptides made from these residues or domains often exhibit the same activity and can be used to derive novel compounds. 

Ludovic Mouhat is an engineer in bioinformatics. He is affiliated to the ERT 62 laboratory and holds a position as a researcher in a biopharmaceutical company. He is involved in the design and chemical production of candidate therapeutic peptide drugs. 

J. A. Vida M. Gordon, Conformationally Directed Drug Design Peptides and Nucleic Acids as Templates or Targets. In ACS Symposium Series 251 American Chemical Society Washington, DC, 1984 pp 9-21. 

In this volume many investigators report on their own studies in conformationally directed drug design. The common theme of all the chapters is the importance of the conformational structure of peptide and nucleic acid in the design of drugs that are either peptide- or nucleic-acid-based or that interact with peptides or nucleic acids. We anticipate that at the present rate of progress significant therapeutic advances will result from... 

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