Pentobarbital calcium

Calcium tail, CjIH94CaN40(, pentobarbital calcium. Nembutal Calcium, Repocal. 

CH4N2O 57-13-6) see Alfuzosin Allantoin Amobarbital Barbital Bromisoval Butalbital Carbasalate calcium Carbromal Cyclopentobarbital Dimethadione Dipyridamole Enoximone Ethotoin Heptabarb Metaxalone Methyclothiazide Orotic acid Paramethadione Pentobarbital Phenacemide Phenetuiide Phenobarbital Phenytoin Proquazone Secbutabarbital Secobarbital Sulfadimethoxine Thalidomide Trimethadione... 

Johnson JD, Conroy WG, Isom GE. 1987. Effect of pentobarbital on cyanide-induced tremors in mice and calcium accumulation in PC12 cells. Biochem Pharmacol 36 1747-1749. 

Incompatibilities Do not mix IV minocycline before or during administration with any solutions containing the following Adrenocorticotropic hormone (ACTH), aminophylline, amobarbital sodium, amphotericin B, bicarbonate infusion mixtures, calcium gluconate or chloride, carbenicillin, cephalothin sodium, cefazolin sodium, chloramphenicol succinate, colistin sulfate, heparin sodium, hydrocortisone sodium succinate, iodine sodium, methicillin sodium, novobiocin, penicillin, pentobarbital, phenytoin sodium, polymyxin, prochlorperazine, sodium ascorbate, sulfadiazine, sulfisoxazole, thiopental sodium, vitamin K (sodium bisulfate or sodium salt), whole blood. 

Several classes of pharmacologic agents are available for insomnia. Barbiturates are the oldest agents that have been used for insomnia and include pentobarbital, secobarbital, and amobarbital. Barbiturates are currently not recommended because of their high abuse potential (due to rapid development of tolerance) and lethal potential in overdose situations. Barbiturates potentiate the GABAergic-induced increase in chloride ion conductance at low doses, and at high doses they depress calcium-dependent action potentials. Caution should be exercised in patients with marked renal or liver dysfunction, severe respiratory disease, suicidal tendencies, or history of alcohol/drug abuse. 

Amobarbital, a barbiturate, is used as a sedative to treat insomnia and as a preanesthetic medication. The barbiturates were used extensively in the past as hypnotic-sedatives but have been replaced by the much safer benzodiazepine derivatives (see Table 9). They do continue to be used as anesthetics (e.g., thiopental) and anticonvulsants (e.g., phenobarbital). The primary mechanism of action of barbiturates is to increase inhibition through the gamma-aminobutyric acid (GABA) system (see Figure 50). Anesthetic barbiturates also decrease excitation via a decrease in calcium conductance. The most commonly used barbiturates are thiopental (Pentothal), methohexital (Brevital), secobarbital (Seconal), pentobarbital (Nembutal), amobarbital (Amytal), and phenobarbital (Luminal). 

---