Pentaerythritol dinitrate

Pentaerythritol Dinitrate [2,2-Bis(hydroxy-methyll-1, 3-propanediol 1,3-di nitrate... 

It is prepd by acetylation of Pentaerythritol Dinitrate (Ref 4). Its impact sensy with a 2kg wt is 175cm for no explns (PA 35cm) (Ref 3). It has been patented as an ingredient in expls, propints, and ign devices (Ref 2)... 

Experiments by Aubertein and Rehling [21] have shown that treatment with water at approximately 100°C causes PETN to hydrolyse. At 125°C, and under pressure, hydrolysis proceeds quite quickly, and is considerably speeded up by the presence of 0.1% of HN03. Whether it occurs in water alone or in water acidified with nitric acid, the hydrolysis produces mainly pentaerythritol dinitrate. A dilute sodium hydroxide solution causes PETN to hydrolyse more rapidly than acidified water. PETN neither reduces Fehling s reagent nor enters into addition products with any aromatic nitro compound. In this respect it differs from both nitroerythritol and nitromannitol. 

Wagner [53] prepared pentaerythritol dinitrate diacetate and pentaerythritol trinitrate monoaoetate and examined their explosive properties. 

Pentaerythritol Cyclic Ether Dinitrate [Oxypentaerythritol Djnitrate, 3,3-Bis-(nitratomethyl)oxetane (name preferred by CA)]. CsH8N207,mw 208.13, N 13.46%, C(CH20N02 v. 

Pentaerythritol Bis[trisfdifluoramino)methyl Ether] Dinitrate, F A-PEDINl. 

Pentaerythritol Tetranitrate (PETN listed as 1,3-Propanediol, 2,2-[bis-(nitroxy)methyl] -dinitrate in CA since 1972, Penta Penthrite in Fr Pentrit, Niperyth, Nitropenta (NP) in Ger TEN in Russ). C(CH20N02)4, mw 316.15,... 

Pentaerythritol Monochlorohydrin Trinitrate 12-Ch loromethy l-2-hydroxy meth y I-1,3-propaned iol Trinitrate (Name preferred by CA)). C5H8C1N309, mw 289.59, N 14.5%, OB to C02 —24.9% a white cryst solid, mp 65—6° (Ref 3) prepd by the action of P pentachloride on Petrin, yield 22.5% (Ref 3). It has been patented as an ingredient for expls, propints, and ign devices (Ref 2). For the expl props of a mixt of this compd with PE dichloride dinitrate, see above under the latter name Refs 1) Beil 1, (2782) 2) Westfalische-An-... 

Cognate Assays The following two pharmaceutical products, namely Pentaerythritol tetranitrate Tablets and Diluted Isosorbide dinitrate are assayed by using a solution of phenoldisulphonic acid as detailed below ... 

The above mechanism of intramolecularly catalyzed cleavage is possible only for compounds with a N02 group close to the departing NO group. In other words, it can be postulated to follow nitro reduction in erythritol tetra-nitrate (9.8), mannitol hexanitrate (9.9), pentaerythritol tetranitrate (9.10), and perhaps trolnitrate (9.14), but not in isosorbide dinitrate (9.11). 

AN, ammonium nitrate DMNB, 2,3-dimethyl-2,3-dinitrobutane 2,4-DNT EGDN, ethylene glycol dinitrate HMX, C4H8N8O8 NG, nitroglycerin NM PETN, pentaerythritol tetranitrate RDX, C3H6N6O6 TATP, triacetone triperoxide TNT, trinitrotoluene UN, urea nitrate TMD, theoretical maximum density. 

Marans and Preckel " synthesized both the mononitrate (95) and the dinitrate (92) esters of metriol by using a similar strategy to that used for pentaerythritol trinitrate. Thus, nitration of both the mono- (90) and the di- (93) acetate esters of metriol, followed by selective hydrolysis of the acetate groups, yields (92) and (95) respectively the latter could be useful as a monomer for the synthesis of energetic polyurethane polymers. 

The main drngs nsed for myocardial ischema therapy and for relieving pain in angina pectoris are nitrates and nitrites (nitroglycerin, isosorbide dinitrate, and pentaerythritol tetranitrate) snbstances that snppress adrenergic systems of the heart—j3-adrenoblockers (atenolol, methoprolol, propranolol, and nadolol), and Ca + channel blockers (verapamil, diltiazem, nifedipine, and nicardipine) as well as a few older drugs, in particular papaverine and dipyridamole. 

At the Bobingen factory hexamine dinitrate is prepared by the action of 50% nitric acid on hexamine at a temperature below 15°C, using spent acid from the nitration of pentaerythritol. NH4N03-HN03 is obtained by the reaction of equi-molecular amounts of ammonium nitrate and concentrated nitric acid. 

Abbreviations Amm Ammonium DNB Dinitrobenzene DNN Dinitronaphthalene DNDFhA Dinitrodiphenylamine GuN Guanidine nitrate HNDPhA Hexanitrodiphenylamine PETN Pentaerythritol Tetranitrate PH- olx Ethyl-enediamine Dinitrate RDX Cyclonite, or Hexogen TNT Trinitrotoluene TNX Trinitroxylene. 

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