Diluted isosorbide dinitrate

Cognate Assays The following two pharmaceutical products, namely Pentaerythritol tetranitrate Tablets and Diluted Isosorbide dinitrate are assayed by using a solution of phenoldisulphonic acid as detailed below ... 

Diluted Isosorbide dinitrate 25 mg 405 nm Each ml of KN03 soln. = 0.934 mg ofC6H8N2Os... 

The former group, where about 98-99% of the pure substance are contained in the sample, is rather inconvenient with respect to the 2 to 3% reproducibility of the method. In the following,(3rd Edition of PhBS III 1970 Pharmacopoea Bohemoslovenica, Editio tertia,) the polarographic determination of the content in pure substances disappeared. The most recent edition of the USP XX also contains articles with polarographic assays, e.g. in case of Phenylmercuric Nitrate, Thimerosal, Diluted Isosorbide Dinitrate, Isosorbide Dinitrate Tablets etc. (Moreover the USP XX contains an excellent general chapter on fundamentals of various polarographic methods),... 

Diluted Isosorbide Dinitrate Isosorbide Dinitrate Tablets Hethazolamide Tablets Nitrofurantoin Nitrofurantoin Tablets Nitrofurantoin Oral Suspension Procarbazine Hydrochloride Capsules... 

Isosorbide dinitrate is used in the treatment of anal fissures. The substance is explosive. For safety reasons it is used as a 40 % dry mixture with a powder base. According to Ph. Eur. it may contain mannitol or lactose monohydrate. Commercially available mixtures usually contain lactose monohydrate and isosorbide dinitrate in a crystalline or amorphous form. They are mixed with the cutaneous base via geometrical dilution (see Sect. 29.4.1). 

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