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Penicillins basophils

Period of tests Skin tests Penicillin Basophil... [Pg.215]

Hematologic/Lymphatic Anemia hemolytic anemia thrombocytopenia thrombocytopenic purpura eosinophilia leukopenia granulocytopenia neutropenia bone marrow depression agranulocytosis reduction of hemoglobin or hematocrit prolongation of bleeding and prothrombin time decrease in WBC and lymphocyte counts increase in lymphocytes, monocytes, basophils, and platelets. Hypersensitivity Adverse reactions (estimated incidence, 1% to 10%) are more likely to occur in individuals with previously demonstrated hypersensitivity. In penicillin-sensitive individuals with a history of allergy, asthma, or hay fever, the reactions may be immediate and severe. [Pg.1477]

Anaphylactic (IgE mediated) Allergen binds to IgE on basophils or mast cells resulting in release of inflammatory medicators Within 30 min Penicillin immediate reaction Blood products Polypeptide hormones Vaccines extra n... [Pg.1600]

Basophils are the least numerous and least well characterized of the circulating leukocytes. While they are not derived from the same progenitor cell as tissue mast cells, basophils and mast cells have several similar functions, including their participation in hypersensitivity reactions. Basophils have also been attributed roles in plasma lipolysis, parasite immunity, tumor cell cytotoxicity, and hemostasis. Increases have been associated with persistent lipemia, parasitism, allergic diseases, certain neoplastic diseases, and administration of certain drugs (e.g., heparin, penicillin). [Pg.23]

Anaphyla. is is a type I reaction in which the drug ( ) interacts with IgE lixed to mast cells contrast media) can produce an anaphylaxis-like (anaphylactoid) reaction on first exposure. [Pg.97]

We have tested this method in investigating 18 patients with a known hypersensitivity to penicillin by clinical and laboratory criteria, and have compared it with other procedures, i.e., skin tests and penicillin RAST. Clinically, all the patients could be classified as showing type I reactions. Six patients were excluded from the study, owing to an insufficiant number of basophils, rendering the test not feasible. [Pg.214]

Table 8. Comparative analysis of the value of skin tests, FAST, and the basophil degranulation test in the diagnosis of type I reactions in 18 patients allergic to penicillin... Table 8. Comparative analysis of the value of skin tests, FAST, and the basophil degranulation test in the diagnosis of type I reactions in 18 patients allergic to penicillin...
Katz HI, Gill KA, Baxter DL, Moschella SL (1964) Indirect basophil degranulation test in penicillin allergy. JAMA 188 351... [Pg.472]

Resnik SS, Shelley WB (1965) Penicillin hypersensitivity detection by basophil response challenge. J invest Dermatol 45 269... [Pg.477]

Shapiro S, Slone D, Siskind V, Lewis GP, Jick H (1970) Ampicillin rashes. Lancet 1 194 Shapiro S, Heinonen OP, Lawson DH (1972) Excess of ampicillin rashes associated with al-lopurinol or hyperuricemia. N Engl J Med 286 505 Sheiman L, Speilvogel AE, Horowitz HI (1968) Thrombocytopenia caused by cephalothin sodium. Occurrence in a penicillin-sensitive individual. JAMA 203 601 Shelley WB (1963) Indirect basophil degranulation test for allergy to penicillin and other drugs. JAMA 184 171... [Pg.479]

The Basophil Activation Test in the Diagnosis of Penicillin Immediate Hypersensitivity... [Pg.153]

See other pages where Penicillins basophils is mentioned: [Pg.49]    [Pg.91]    [Pg.119]    [Pg.1576]    [Pg.499]    [Pg.132]    [Pg.215]    [Pg.224]    [Pg.226]    [Pg.456]    [Pg.466]    [Pg.867]    [Pg.75]    [Pg.86]    [Pg.117]    [Pg.821]    [Pg.467]   
See also in sourсe #XX -- [ Pg.456 ]



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