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Basophil degranulation test

We have tested this method in investigating 18 patients with a known hypersensitivity to penicillin by clinical and laboratory criteria, and have compared it with other procedures, i.e., skin tests and penicillin RAST. Clinically, all the patients could be classified as showing type I reactions. Six patients were excluded from the study, owing to an insufficiant number of basophils, rendering the test not feasible. [Pg.214]

The results shown in Table 8 demonstrate an excellent correlation of skin tests and RAST with the clinical diagnosis. The correlation is, however, much lower for the basophil degranulation test. Interestingly, this result improved when the test was performed several days after the clinical reaction had taken place. Such a study should be extended to other drugs in order to test its feasibility with less well-characterized antigenic determinants. [Pg.214]

Period of tests Skin tests Penicillin Basophil [Pg.215]

RAST (radioallergosorbent test) or enzyme assay (IgE, IgG) Histamine liberation from granulocytes Basophil degranulation test Passive hemagglutination Lymphocyte transformation test Macrophage inhibition test Rosette test... [Pg.154]

Table 8. Comparative analysis of the value of skin tests, FAST, and the basophil degranulation test in the diagnosis of type I reactions in 18 patients allergic to penicillin... Table 8. Comparative analysis of the value of skin tests, FAST, and the basophil degranulation test in the diagnosis of type I reactions in 18 patients allergic to penicillin...
Benveniste J (1981) The human basophil degranulation test as an vitro method for the diagnosis of allergies. Clin Allergy 2 1... [Pg.466]

Katz HI, Gill KA, Baxter DL, Moschella SL (1964) Indirect basophil degranulation test in penicillin allergy. JAMA 188 351... [Pg.472]

Shapiro S, Slone D, Siskind V, Lewis GP, Jick H (1970) Ampicillin rashes. Lancet 1 194 Shapiro S, Heinonen OP, Lawson DH (1972) Excess of ampicillin rashes associated with al-lopurinol or hyperuricemia. N Engl J Med 286 505 Sheiman L, Speilvogel AE, Horowitz HI (1968) Thrombocytopenia caused by cephalothin sodium. Occurrence in a penicillin-sensitive individual. JAMA 203 601 Shelley WB (1963) Indirect basophil degranulation test for allergy to penicillin and other drugs. JAMA 184 171... [Pg.479]

Additional biological tests have been suggested to improve the accuracy further. The leukocyte histamine release test has been found helpful (75) but it is expensive and time-consuming. Several surface molecules have been studied as markers, for example CD63. IgE-mediated degranulation of basophils after incubation of the patient s serum with a neuromuscular blocking agent can... [Pg.2491]

See other pages where Basophil degranulation test is mentioned: [Pg.52]    [Pg.54]    [Pg.214]    [Pg.214]    [Pg.224]    [Pg.226]    [Pg.456]    [Pg.52]    [Pg.54]    [Pg.214]    [Pg.214]    [Pg.224]    [Pg.226]    [Pg.456]    [Pg.141]    [Pg.172]    [Pg.248]    [Pg.114]    [Pg.340]    [Pg.340]    [Pg.388]    [Pg.570]    [Pg.278]    [Pg.174]    [Pg.433]    [Pg.241]    [Pg.214]    [Pg.684]    [Pg.63]    [Pg.118]    [Pg.340]   
See also in sourсe #XX -- [ Pg.154 ]



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