Pemetrexed

Folate antagonists Methotrexate Ralitrexed Pemetrexed (alimta)... [Pg.147]

The recommended dose of pemetrexed is 500 mg/m2 administered as an intravenous infusion over 10 min on Day 1 of each 21-day cycle. Pemetrexed is not metabolized to an appreciable extent and is primarily eliminated in the urine, with 70-90% of the dose recovered unchanged within the first 24 h following administration. Pemetrexed has a steady-state volume of distribution of 16.1 L. Pemetrexed is highly bound (approximately 81%) to plasma proteins. Binding is not affected by the degree of renal impairment. Plasma... [Pg.148]

Pemetrexed Pemetrexed 500 mg/m2 (day 1), vitamin B12 1 mg IM 1-2 weeks before treatment initiation and every 9 weeks thereafter, folic acid 1 mg daily beginning 3 weeks before treatment initiation 21 days 5-6%... [Pg.1330]

Docetaxel, pemetrexed, and an oral epidermal growth factor receptor inhibitor, erlotinib, are options for unresectable stage III or IV NSCLC patients with good performance status who progress during or after first-line therapy. [Pg.715]

Table 23.1 details all of the recent Food and Drug Administration (FDA)-approved agents. In this section we will detail some interesting aspects of the approach to their development. As can be seen in Table 23.1 there are 21 new entities. Of note is that only seven (33%) of the agents including capecitabine, liposomal doxorubicin, temozolomide, and oxaliplatin, ABl-007, liposomal cytarabine, and pemetrexed could be considered conventional cytotoxic... [Pg.446]

Pemetrexed (AlimtaT ) Multitargeted antrfole Mesothelioma non-small ceU lung Phase III... [Pg.447]

A much more conventional approach was required for the approval of pemefrexed for the treatment of patients with advanced mesothelioma. In a trial of cisplafinum plus pemetrexed vs. cisplafinum alone, there was a significant improvement in patient survival (a median of 13 vs. 10 months). In addition to an improvement in survival, the trial also had patient-oriented endpoints such as amount of dyspnea and an improvemenf in vital capacity (e.g., clinical benefit). There is no doubt that future clinical trials should build upon these important patient-oriented endpoints, particularly trials in which response (tumor shrinkage) may not be as commonly seen as the response with cytotoxic agents. ... [Pg.448]

Vogelzang, N.J. et al.. Phase III study of pemetrexed in combination with cisplatm versus cis-platin alone in patients with malignant pleural mesothelioma, /. Clin. Oncol, 21, 2636-2644, 2003. [Pg.455]

Hanna, N. et al.. Randomized phase IE trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy, /. Clin. Oncol, 22,... [Pg.455]

Methotrexate (Rheumatrex Dose Pack, TrexaU) Nelarabine (Arranon) Pemetrexed (Alimta) 6-Thioguanine [6-TG] (Tabloid)... [Pg.38]

Panitumumab (Vectibix) Pemetrexed (Alimta) Rasburicase (Elitek) Sorafenib (Nexavar) Sunitinib (Sutent) Temsirolimus (Torisel Kit)... [Pg.39]

Uses w/ cisplatin in nonresectable mesothelioma NSCLC Action Antifolate antineoplastic Dose 500 mg/m IV over 10 min q3wk hold if CrCl <45 mLAnin give w/ vit Bi2 (1000 meg IM q9wk) folic acid (350-1000 meg PO daily) start 1 wk before dexamethasone 4 mg PO bid x 3 start 1 d before each Rx Caution [D, -] w/ renal/hepatic/ BM impair Contra Component sensitivity Disp IV SE Neutropenia, thrombocytopenia, N/V/D, anorexia, stomatitis, renal failure, neuropathy, fevCT, fatigue, mood changes, dyspnea, anaphylactic Rxns Interactions t Effects W/ NSAIDs, probenecid d/t decreased pemetrexed EMS Monitor for S/Sxs of Infxn OD May cause profound BM suppression, mucous membrane irritation, D, and rash symptomatic and supportive... [Pg.250]

Pemetrexed is chemically similar to folic acid. It inhibits three enzymes used in purine and pyrimidine synthesis - thymidylate synthetase, dihydrofolate reductase, and glycinamide ribonucleotide formyl transferase. By inhibiting the formation of precursor purine and pyrimidine nucleotides, pemetrexed prevents the formation of DNA and RNA. In 2004 it was approved for treatment of malignant pleural mesothelioma and as a second-line agent for the treatment of non-small cell lung cancer. Adverse effects include gastrointestinal complaints, bone marrow suppression, alopecia, allergic and neurotoxic reactions. [Pg.452]

Pemetrexed Inhibits TS, DHFR, and purine nucleotide synthesis Mesothelioma, non-small cell lung cancer Myelosuppression, skin... [Pg.1170]

Pemetrexed Alimta Mesothelioma Blood disorders (anemia, leukopenia, thrombocytopenia] allergic reaction... [Pg.572]

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