Probenecid Pemetrexed

Uses w/ cisplatin in nonresectable mesothelioma NSCLC Action Antifolate antineoplastic Dose 500 mg/m IV over 10 min q3wk hold if CrCl <45 mLAnin give w/ vit Bi2 (1000 meg IM q9wk) folic acid (350-1000 meg PO daily) start 1 wk before dexamethasone 4 mg PO bid x 3 start 1 d before each Rx Caution [D, -] w/ renal/hepatic/ BM impair Contra Component sensitivity Disp IV SE Neutropenia, thrombocytopenia, N/V/D, anorexia, stomatitis, renal failure, neuropathy, fevCT, fatigue, mood changes, dyspnea, anaphylactic Rxns Interactions t Effects W/ NSAIDs, probenecid d/t decreased pemetrexed EMS Monitor for S/Sxs of Infxn OD May cause profound BM suppression, mucous membrane irritation, D, and rash symptomatic and supportive... 

PEMETREXED ANTIGOUT DRUGS -PROBENECID t pemetrexed levels Probable 1 renal excretion of pemetrexed Avoid co-administration where possible. If both need to be given, monitor FBC and renal function closely and watch for gastrointestinal disturbance and features of myopathy... 

It is possible that drugs that are secreted by the renal tubules (e.g. probenecid, penicillin) could decrease the clearance of pemetrexed, which is also secreted by this mechanism. For this reason, the manufacturer recommends caution with combined use, and, if necessary, close monitoring of creatinine clearance. ... 

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