PDGF , signal transduction

Gilbert RE, Kelly DJ, McKay T, Chadban S, Hill PA, Cooper ME, Atkins RC, Nikolic-Paterson DJ (2001) PDGF signal transduction inhibition ameliorates experimental mesangial proliferative glomerulonephritis. Kidney Int 59 1324-1332... 

Lo, H-M, C-F Hung, Y-L Tseng, B-H Chen, J-S Jian, and W-B Wu. 2007. Lycopene binds PDGF-Bb and inhibits PDGD-BB-induced intracellular signaling transduction pathway in rat smooth muscle cells. Biochem Pharmacol 74 54-63. 

SU-6656 (12) [113-115] is a potent inhibitor of Src kinase (as well as Lck, Fyn, and Yes kinases) and is an effective inhibitor of PDGF-stimulated DNA synthesis and Myc induction in a fibroblast cell line. SU-6656 has also been a useful tool for investigating the role of Src and Ras-ERK signal transduction in Src-transformed cells with respect to Racl, as well as implicating Vav2 and Tiaml as downstream effectors of Src to modulate Racl-dependent pathways. In endothelial cells, SU-6656 is effective in increasing radiation-induced apoptosis and vascular endothelium destruction, and in vivo studies have... 

Ahn, H.Y., Hadizadeh, K.R., Seul, C., Yun, Y.P., Vetter, H., and Sachinidis, A., Epigallocathe-chin-3-gallate selectively Inhibits the PDGF-BB-induced intracellular signaling transduction pathway in vascular smooth muscle cells and inhibits transformation of ai-transfected NIH 3T3 fibroblasts and human glioblastoma cells (A172), Mol. Biol. Cell, 10, 1093, 1999. 

In the other pathway, an additional adaptor protein, the She protein (see 8.5), is involved in the signal transduction. The She protein has a phosphotyrosine binding domain (PTB domain) and specifically binds via this domain to autophosphorylated receptors such as the PDGF receptor and the EGF receptor. The She protein is phos-phorylated itself in the process. The phosphotyrosine residues may also serve as attachment points for the SH2 domain of Grb2 protein, whereby the Grb2-Sos complex is attached to the membrane. 

A. Eriksson, A. Siegbahn, B. Westermarlq C. H. Heldin, and L. Claesson Welsh. PDGF alpha- and beta-receptors activate unique and common signal transduction pathways. EMBOJ, 11 (2), 543-550,1992. 

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