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Patches drugs

Other than possibly for the insensible perspiration they absorb, transdermal patches tend to operate as thermodynamically static systems, meaning as com-positionally fixed systems, from the moment they are applied until their removal. Marketed ethanol-driven estradiol and fentanyl patches are exceptions because they meter out ethanol and drive it into the stratum corneum to propel the absorption process. Compositional steadfastness is still the rule, however, and it is this feature that bestows the zero-order delivery attribute on the ordinary transdermal patch. Drug is present within the patches in reservoir amounts whether or not the reservoir compartment is easily distinguished, for there must be enough drug to sustain delivery over the full course of patch wear. [Pg.232]

Li, C. Koch, R.L. Raul, V.A. Bhatt, P.P. Johnston, T.P. Absorption of thyrotropin releasing hormone in rats using a mucoadhesive buccal patch. Drug Dev. Ind. Pharm. 1997, 23, 239-246. [Pg.2677]

Injectable products Pellets 10-400 mgIM every 2-4 weeks 150-450 mg/implant every 3-6 months apnea, aggressive behavior, erythrocytosis, skin reaction to patches, drug absorption by sex partner therapy... [Pg.1656]

Sutinen, R., A. Urtti, V. Saano, and P. Paronen. 1993. Water-activated and pH-controlled transdermal patch Drug absorption and skin irritation. In Prediction of percutaneous penetration, vol. 3b. Edited by K. R. Brain V. J. James, and K. A. Walters. Cardiff, UK STS Publishing, pp. 554-557. [Pg.578]

Uses Plasticizer for PVC, NC, CAP, chlorinated rubber, epoxies for insulation, upholstery, window channels, liners, gaskets, coated fabrics pigment grinding medium nonmigratory in paper coatings plasticizer in pharmaceuticals skin patch drug delivery ManuWistrib. C.P. Hall... [Pg.1293]

Transdermal patches Drug-containing laminates attached to the skin with an adhesive. Drug contained in the laminate migrates from the patch through... [Pg.214]

Perhaps a more specialized case of using plasticizers in acrylic formulations can be found in drug delivery patches. Here, plasticizing additives called excipients... [Pg.504]

These include atropine, scopolamine (hyoscine), trihexyphenidyl (benzhexol) and benzatropine. They block central muscarinic receptors involved in various afferent pathways of the vomiting reflex (Fig. 1). They have been used to control motion sickness, emesis in Meniere s disease and postoperative vomiting. Currently, hyoscine is largely restricted to the treatment of motion sickness where it has a fast onset of action but a short duration (4-6 h). Administration of hyoscine by transdermal patch produces a prolonged, low-level release of the drug with minimal side effects. To control postoperative vomiting, it should be applied >8 h before emesis is anticipated. [Pg.462]

Dru may be applied to the skin and mucous membranes using several routes topically (on the outer layers of skin), transdermally through a patch on which the drug has been implanted, or inhaled through the membranes of the upper respiratory tract. [Pg.25]

Additional education regarding special considerations of certain drugs, such as techniques for giving injections, applying topical patches, or instilling eye drops... [Pg.54]

Fentanyl transdermal is a transdermal system that is effective in the management of the severe pain associated with cancer. The transdermal system allows for a timed-release patch containing the drug fentanyl to be activated over a 72-hour period. A small number of patients may require systems applied every 48 hours. The nurse monitors for adverse effects in the same manner as for other narcotic analgesics (eg, the nurse notifies the primary health care provider if the respiratory rate is 10/min or less). [Pg.174]

Topical antipsoriatics are drugs used in the treatment of psoriasis (a chronic skin disease manifested by bright red patches covered with silvery scales or plaques). These drug help remove tiie plaques associated with this disorder. Examples of antipsoriatics include antiiralin (Anthra-Derm) and calcipotriene (Dovonex). [Pg.610]

Transdermal patches arc applied to the skin. The drug is mixed with the adhesive for the patch, and so it lies next to in readily absorb many chemicals and so uch as nitroglycerin (for heart disease),... [Pg.17]

Rohsenow DJ, Monti PM, Colby SM, et al Naltrexone treatment for alcoholics effect on cigarette smoking rates. Nicotine Tob Res 5 231-236, 2003 Rose JE, Levin ED Concurrent agonist-antagonist administration for the analysis and treatment of drug dependence. Pharmacol Biochem Behav 41 219—226, 1991 Rose JE, Behm FM, Westman EC, et al Mecamylamine combined with nicotine skin patch facilitates smoking cessation beyond nicontine patch treatment alone. Clin Pharmacol Ther 56 86-99, 1994... [Pg.337]

The primary characteristic of a sequential blocker, as observed with the patch clamp technique, is that the reciprocal of the mean duration of the lifetime equals the normal channel closing rate plus the rate constant of channel blockade times the drug concentration. Therefore, increasing the drug concentration shortens the mean channel open time. [Pg.114]

False. Nicotine is a highly addictive drug and the smoking habit can be very difficult to stop. Many people have to resort to medication, such as nicotine patches or gum, to help them stop. The best plan is never to start. [Pg.90]

These approaches to receptor identification and classification were, of course, pioneered by studies with peripheral systems and isolated tissues. They are more difficult to apply to the CNS, especially in in vivo experiments, where responses depend on a complex set of interacting systems and the actual drug concentration at the receptors of interest is rarely known. However, the development of in vitro preparations (acute brain slices, organotypic brain slice cultures, tissue-cultured neurons and acutely dissociated neuronal and glial cell preparations) has allowed more quantitative pharmacological techniques to be applied to the action of drugs at neurotransmitter receptors while the development of new recording methods such as patch-clamp... [Pg.58]


See other pages where Patches drugs is mentioned: [Pg.14]    [Pg.3771]    [Pg.14]    [Pg.3771]    [Pg.232]    [Pg.125]    [Pg.486]    [Pg.502]    [Pg.525]    [Pg.128]    [Pg.26]    [Pg.133]    [Pg.337]    [Pg.386]    [Pg.403]    [Pg.598]    [Pg.39]    [Pg.36]    [Pg.326]    [Pg.76]    [Pg.267]    [Pg.77]    [Pg.449]    [Pg.188]    [Pg.582]    [Pg.202]    [Pg.207]    [Pg.208]    [Pg.216]    [Pg.217]   


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Administration, drugs patches, topical application

Buccal drug delivery adhesive patches

Drug delivery patches

Drug delivery patches Subject

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Drug formulations transdermal patches

Patches

Receptor patches destruction by drugs

Transdermal Drug Delivery Systems (Patches)

Transdermal patches drug reservoir patch

Transdermal patches with drug substances

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