Lubricant sensitivity

Native starches are used as disintegrants, diluents, and wet binders. However, their poor flow and high lubricant sensitivity make them less favorable in direct compression. Different chemical, mechanical, and physical modifications of native starches have been used to improve both their direct compression and controlled-release properties (Sanghvi, 1993 van Aerde and Remon, 1988). Schinzinger and Schmidt (2005) used potato starch as an excipient and compared its granulating behavior with a-lactose-monohydrate and di-calcium phosphate anhydrous in a laboratory fluidized bed granulator using statistical methods. 

Flow properties, lubricant sensitivity, aggregation potential, bulk density, compressibility, hygroscopicity... 

Surface roughness Flow ability, segregation potential, dilution potential, lubricant sensitivity... 

Anhydrous 3-lactose (95%) and lactitol (5%) Pharmatose DCL14 DMY, Veghel, The Netherlands High compactibility, superior flowing properties, low lubricant sensitivity... 

Bolhuis, G. K., and Holzer, A. W., Lubricant sensitivity. VIII. Effect of third components on the film formation of lubricants. In Alberborn G, Nystrom C Eds. Pharmaceutical Powder Compactation Technology, New York Marcel Dekker 1996, pp 550-555. 

The mechanical strength of the tablets and lubricant sensitivity were found fo be dependenf upon fhe marmifol confenf and fhe processing... 

Bolhuis, G.K. Holzer, A.W. Lubricant sensitivity. In Pharmaceutical Powder Compaction Technology Alderborn, G., Nystrom, C., Eds. Marcel Dekker, Inc. New York, 1996 517-560. 

Starch is a very widely used tablet excipient, but in its natural state, it does not possess the fluidity and binding characteristics needed as a tablet diluent. The major consolidation mechanism of starch is by deformation with a high elastic component.In addition, starch shows a high degree of lubricant sensitivity. 

Bos CE, Vromans H, Lerck CF. Lubricant sensitivity in relation to bulk density for granulations based on starch or cellulose. Int ] Pharm 1991 67 39-49. 

Avicel HFE-102 is a new, proprietary cospray-dried MCC/mannitol high functionality binding excipient for direct compression. The cospray drying added extra benefits to the excipient as it changed its properties combining the high compactibility of MCC and the low lubricant sensitivity of mannitol. The outcome was a harder, less friable, and faster disintegrating tablet. 

G. K. BoUiuis and A. W. Holzer, Lubricant sensitivity , in G. Alderbom and C. Nystrom, eds.. Pharmaceutical Powder Compaction Technology, Marcel Dekker, New York, 1996. 

Lubricant Sensitivities , R. I. Taylor, SAE Spring Fuels and Lubricants Conference, Paris, 2000... 

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