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PARPs polymerases

Ame J-C et al. PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase. J Biol Chem 1999 274 17860-17868. [Pg.124]

Ataxia telangiectasia mutated (ATM), poly(ADP ribose) polymerase (PARP), DNA-dependent protein kinase, DNA replication factor C, DNA topoisomerase I, DNA fragmentation factor (DFF)45, inhibitor of caspase-activated DNAse (ICAD), lamins A, Bl, and C TRAF-1, Rafl, Ras, GAP, GDP dissociation inhibitor of Rho family GTPases, phospholipase A2, Statl... [Pg.604]

PARP polyADP-ribose polymerase PtdOH phosphatidic acid... [Pg.966]

Abstract Poly(ADP-Ribose) Polymerase-1 (PARP-1) is the prototypical and most abundantly... [Pg.45]

BRCT BRCAl C-terminus-like DBD DNA-binding domain dPARP Drosophila PARP MPTP l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine NAD+ Nicotinamide adenine dinucleotide NAm Nicotinamide NLS Nuclear locahzation signal OAADPR O-acetyl-ADP-ribose PAR Poly(ADP-ribose) PARG Poly(ADP-ribose) glycohydrolase PARP Poly(ADP-ribose) polymerase PARylation poly(ADP-ribosyl)ation... [Pg.45]

Ame JC, Rolli V, Schreiber V, Niedergang C, Apiou F, Decker P, Muller S, Hoger T, Menissier-de Murcia J, de Murcia G (1999) PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase. J Biol Chem 274 17860-17868... [Pg.64]

Kun E, Kirsten E, Ordahl CP (2002) Coenzymatic activity of randomly broken or intact double-stranded DNAs in auto and histone HI trans-poly(ADP-ribosylation), catalyzed by poly(ADP-ribose) polymerase (PARP I). J Biol Chem 277 39066-39069 Kun E, Kirsten E, Mendeleyev J, Ordahl CP (2004) Regulation of the enzymatic catalysis of poly(ADP-ribose) polymerase by dsDNA, polyamines, Mg2-F, Ca2-F, histones HI and H3, and ATP. Biochemistry 43 210-216... [Pg.66]

Saxena A, Wong L, Kalitsis P, Earle E, Schaffer L, Choo KHA (2002b) Poly(ADP-ribose) polymerase 2 localizes to mammalian active centromeres and interacts with PARP-1, Cenpa, Cenpb, Bub3, but not Cenpc. Hum Mol Genet 11 2319-2329... [Pg.68]

TuUn A, Spradling A (2003) Chromatin loosening by poly(ADP)-ribose polymerase (PARP) at Drosophila puff loci. Science 299 560—562... [Pg.70]

TuUn A, Stewart D, Spradling A (2002) The Drosophila heterochromatic gene encoding poly(ADP-ribose) polymerase (PARP) is required to modulate chromatin structure during development. Genes Dev 16 2108-2119... [Pg.70]

PARP binds to DNA surrounding single- or double-strand breaks and attaches polymers of ADP-ribose to itself and other proteins. This increases the negative charge in this area, thus facilitating DNA repair. Payne et al. reported increased poly(ADP-ribose) polymerase (PARP) activity in Jurkat cells treated with sodium deoxycholate. Activation of PARP in colonic cells was similarly reported by Glinghammer et al " following treatment with this bile acid. [Pg.75]

Schelman WR, Sandhu SK, Moreno GV et al (2011) First-in-human trial of a poly(ADP)-ribose polymerase (PARP) inhibitor MK-4827 in advanced cancer patients with antitumor activity in BRCA-deficient tumors and sporadic ovarian cancers (soc). J Clin Oncol 29 abstr 3102... [Pg.136]

Wiltshire TD, Lovejoy CA, WangT et al (2010) Sensitivity to polyADP-ribose polymerase PARP inhibition identifies ubiquitin-specific peptidase 11 USPll as a regulator of DNA double-strand break repair. J Biol Chem 285 14565-14571... [Pg.137]

See other pages where PARPs polymerases is mentioned: [Pg.96]    [Pg.230]    [Pg.231]    [Pg.363]    [Pg.575]    [Pg.570]    [Pg.605]    [Pg.11]    [Pg.229]    [Pg.348]    [Pg.291]    [Pg.253]    [Pg.46]    [Pg.65]    [Pg.66]    [Pg.68]    [Pg.70]    [Pg.70]    [Pg.70]    [Pg.167]    [Pg.465]    [Pg.451]    [Pg.464]    [Pg.258]    [Pg.313]    [Pg.4]    [Pg.126]    [Pg.255]    [Pg.89]    [Pg.101]    [Pg.75]   


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