Lincomycin, hydrochloride monohydrate

Lincos amides clindamycin hydochloride clindamycin palmitate hydrochloride clindamycin phosphate lincomycin hydrochloride monohydrate... 

It is routine to standardize Karl Fischer reagents, or even a coulometer, with a standard such as lincomycin hydrochloride monohydrate, which contains 3.91 wt% H20. The coulometer is run until the end point is reached, indicating that the Karl Fischer reagent is dry. A port is opened briefly to add solid lincomycin, which is then titrated to the same end point. Then an unknown is added and titrated in the same manner. Find the wt% HzO in the unknown. 

Lincomycin hydrochloride (anhydrous) 8S9 - 18 - 7 Lincomycin hydrochloride (monohydrate) 7179- 49 9... 

Lincomycin hydrochloride monohydrate is a white or almost white, crystalline powder. It is odorless or has a faint mercaptan - like odor and has a bitter taste. 

A suitable sample of lincomycin hydrochloride monohydrate was obtained by the generosity of the Upjohn Company ( USA ) with the following date ... 

A typical potassium chloride disc spectrum of lincomycin hydrochloride monohydrate is shown in Figure (I), form B. The spectrum shows two strong bands at lOSScm and 1564 cm-1 attributed to the amide group in addition to abroad band at 3700 - 3100 cm-1( A OH and AnH). Other bands were observed at 1262 cm-1,1104 cnr1,1075 cm 1and 1040 cm-1. 

Lincomycin hydrochloride monohydrate can be detected by paper chromatography. The method employed was paper chromatography followed by bioautography on agar frays seeded with Sarcinea Lutea. The following solvent systems were used ... 

Lincomycin hydrochloride monohydrate (100 mg) was dissolved in a mixture of 5 % mercuric acetate ( 3 ml) and glacial acetic acid (30 ml). The resulted solution was titrated with 0.1 N HCIO4 in which the end - point was detected potentiometrically. Each ml of HCIO4 is equivalent to 23.05 mg of lincomycin hydrochloride monohydrate. 

It has been reported that lincomycin cycloamate dihydrate is more thermally stable in the solid state than lincomycin hydrochloride monohydrate (65). 

Albiotic Cillimycin Frademicina Lincocin [as hemihydratel Lincomix Lincomycin hydrochloride Lincomycin, hydrochloride hydrate Lincomycin hydrochloride monohydrate Mycivin NSC 70731 Waynecomycin. Antibacterial, White powder mp = 145-147° [a]S = 137 (H2O) freely soluble in H2O, MeOH, EtOH sparingly soluble in most organic solvents LDso (mus, rat orl) = 4000 mg/kg, (mus, rat ip) = 1000 mg/kg. Phamaoie Upjohn. 

Lincomycin hydrochloride monohydrate Neomycin palmitate Paromomycin sulfate Potassium penicillin O Potassium phenethicillin Rolitetracycline Sodium cephalothin Sodium cloxacillin monohydrate Sodium colistimethate Sodium dicloxacillin monohydrate Sodium methicillin monohydrate Sodium nafcillin monohydrate Sodium oxacillin monohydrate Spectinomycin dihydrochloride pentahydrate Vancomycin sulfate Viomycin sulfate... 

The two forms showed two different infra - red spectra (8) (Figure i). Form A is a hemihydrate and consisted of light, fluffy, needle - like crystals (9). The second form of crystals, B, existed as small, dense cubic crystals, m.p. 145 147°C (10). This form existed as a monohydrate. Polymorphic form B is the commercially available material. The two forms result from differing conditions of crystallization. Form A was obtained when acetone was added quickly without stirring to an aqueous solution of lincomycin hydrochloride. The mixture was allowed to stand 3-6 minutes while maintained at 5-10 °C, during which time crystallization took place. However, form B separated when the acetone was added slowly (at a rate of 20 - 25 ml. per minute) and the mixture maintained at 30 35 °C with stirring for four hours. 

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