Paralysis by analysis

It will avoid the current paralysis-by-analysis syndrome where we have upwards of 30 000 chemicals on the market that have not been adequately tested. Substitution reduces the need for cumbersome, time-consuming, subjective and data-poor assessments of risk. If an alternative is available which is intrinsically less hazardous, intensive assessment of the original hazardous chemical is unnecessary. 

To avoid wasting resources by overretining assessments, avoid paralysis by analysis, and reassure stakeholders that the assessment process is finite, criteria are needed for deciding when to stop. 

To return for a moment to the traditional models, they have been expanded, elaborated upon and mixed in all possible (and some impossible) proportions and, with the willing aid of modern computational methods, developed to a level of complexity that is in some cases out of touch with reality and certainly no longer physically imaginable but this process of paralysis by analysis is the fate of many originally simple ideas. Fortunately fluidised bed reactor models are still reasonably closely related to what actually happens and by and large the models can still be imagined as physical realities. 

Function 3. Financial Management. Failure to properly assess financial resources Is cited as a major cause of failure for Individual entrepreneurs and small businesses. In contrast, large corporations often overdo financial evaluation and analysis of the prospects of a new Idea. Indeed, the new-Idea champions in a corporation rightly complain of "paralysis by analysis" and feel that few Innovative Ideas can get through these corporate filters. 

Musculoskeletal Effects. After accidental exposure to a large amount of barium carbonate powder by acute inhalation, a 22-year-old factory worker developed progressive muscle weakness and paralysis of the extremities and neck (Shankle and Keane 1988). X-ray analysis of the bones and skeletal muscles of the pelvis and thighs of workers chronically exposed to barium carbonate dust revealed no apparent build up of barium in these tissues (Essing et al. 1976). No studies were located regarding musculoskeletal effects in animals after inhalation exposure to barium. 

While scant literature is available on persistence and distribution after inhalation exposure, several studies have evaluated the systemic behavior of parenterally administered toxins. One group investigated toxin persistence in serum and tissue distribution in white mice following intravenous (IV) administration of 1,000 lethal doses of S-labeled type B toxin (Pak and Bulatova, 1962). Mice were sacrificed at 20, 60, and 150 min after toxin administration, and blood and tissues were harvested for toxin distribution analysis. These mice showed symptoms of severe intoxication, including atypical breathing patterns and paralysis, at 150 min post-exposure. Toxin levels (as determined by... 

Several studies investigated the in vivo toxicity of macrocyclic trichothecenes [135], It is assumed that their toxic effects are based on the inhibition of protein synthesis, with a slowly progressing respiratory depression and paralysis of skeletal muscles. The epidermal remains of these plant species that produce acute intoxication in rumiants were also quantified by microhistological analysis in the gastrointestinal content of sheep which had been experimentally poisoned [136]. 

Somkuti et al. (1987) reported testicular toxicity of TOCP in adult leghorn roosters. Birds dosed with 100 mg/kg/day exhibited limb paralysis in 7-10 days. Such symptoms are characteristics of delayed neurotoxicity caused by organophosphorus compounds. Analysis at the termination of 18 days indicated a significant inhibition of neurotoxic esterase activity in both brain and testes, and a decrease in sperm motility and brain acetylcholinesterase activity. 

There are several fairly robust methods for functional analysis of hind limbs, particularly in rats. Behaviors such as walking (Basso et al., 1995) or swimming (Xu et al., 2015) are analyzed using scoring protocols or by computerized monitoring of the gait (Hamers et al., 2001). A remaining problem is that the assessment methods that can be used in animals from complete paralysis to mild deficits in coordination... 

Figure 21.8 Model of human skull with a possible implementation of an implantable EPAM actuator for eyelid reanimation. The arrow indicates the EPAM module with slings for the upper and lower eyelids (Reprinted with permission from Laryngoscope, Restoration of Eyelid Closure in Eacial Paralysis Using Artificial Muscle Preliminary Cadaveric Analysis by Tollefson, T.T. and Senders, C.W, 117, 11, 1907-11. Copyright (2007) Lippincott, Williams and Wilkins).

With respect to analysis of venoms of insect predators, the most familiar species studied are the predatory wasps. However, there are also other insect species that are likely to possess interesting toxins relevant to uses in basic research. For example, the molecules causing rapid paralysis that are used by predatory wasps (e.g. kinins) are likely not the same as those used by other kinds of wasps whose venom causes paralysis only after a period of time, sometimes days. 

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