Parallelism advantage, selectors

Our group also demonstrated another combinatorial approach in which a CSP carrying a library of enantiomerically pure potential selectors was used directly to screen for enantioselectivity in the HPLC separation of target analytes [93, 94]. The best selector of the bound mixture for the desired separation was then identified in a few deconvolution steps. As a result of the parallelism advantage , the number of columns that had to be screened in this deconvolution process to identify the single most selective selector CSP was much smaller than the number of actual selectors in the library. 

The most important advantages of direct chromatographic enantioseparations for preparative purposes include the presence of resolved enantiomers in original and high optically pure form in different volume fractions of the mobile phase, no loss of chiral selectors, and amost no risk of contamination of desired enantiomers with the chiral selector. Parallel to enantioseparations other impurities may be removed from chiral compounds during this process. 

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