P-Hydroxyethylamine

Reaction of cyanohydrins with absolute ethanol in the presence of HCl yields the ethyl esters of a-hydroxy acids (3). A/-substituted amides can be synthesized by heating a cyanohydrin and an amine in water. Thus formaldehyde cyanohydrin and P-hydroxyethylamine lead to A/- (P-hydroxyethyl)hydroxyacetamide (4). 

Synonyms AI3-24219 2-Aminoethanol p-Aminoethyl alcohol BRN 0505944 Caswell No. 426 CCRIS 6260 Colamine EINECS 205-483-3 EPA pesticide chemicai code 011601 P-Ethanolamine Ethylolamine Glycinol 2-Hydroxyethylamine p-Hydroxyethylamine MEA Monoethanolamine Olamine Thiofalco M-50 UN 2491 USAF EK-1597. 

Hydroxyethylamine, see Ethanolamine p-Hydroxyethylamine, see Ethanolamine 2-Hydfroxyethyl chloride, see Ethylene chlorohydrin... 

Deacetylvinblastine acylazide (62) was later shown to be an exceptionally versatile intermediate for the preparation of C-3 amides. Since nucleophilic displacement of azide occurs at relatively low temperatures under mild conditions, a wide variety of C-3 derivatives have been prepared (Scheme 1, Table III). This observation is in contrast to the direct amino-lysis of vinblastine which usually fails when the amine employed is substituted (e.g., p-hydroxyethylamine) or secondary (dimethylamine). The reactions can be conveniently followed by the disappearance of the CO—N, infrared band at 2135 cm" with the concomitant appearance of the CO—NHj band in the region 1665-1675 cm". Acetylation of the... 

Synonym p-aminoethyl alcohol, ethylolamine, 2-hydroxyethylamine, p-hydroxyethylamine, monoethanolamine, MEA... 

ISOPROPYLAMINOMETHYL-3,4-DIHYDROXY-PHENYL CARBINOL a-(ISOPROPYLAMINO-METHYL)PROTOCATECHUYL ALCOHOL ISOPROPYLARTERENOL N-ISOPROPYL- 3-DIHYDROXYPHENYL-p-HYDROXYETHYLAMINE ISOPROPYL NORADRENALINE N-ISOPROPYL-NORADRENALINE 1-ISOPROPYLNORADRENALINE... 

Synonyms 2-Ami noethanol 2-Ami noethyl alcohol p-Aminoethyl alcohol p-Ethanolamine Ethylolamine Glycinol 2-Hydroxyethylamine p-Hydroxyethylamine MEA MELA Monoethanolamine Classification Aliphatic amino alcohol alkanolamine Empirical C2H7NO Formula NH2CH2CH2OH Properties Colorless clear mod. vise, liq. ammoniacal odor misc. with water, alcohol, acetone, glycerin sol. in chloroform si. sol. in benzene m.w. 61.10 dens. 1.012 vapor pressure 0.26 mm Hg m.p. 10.5 C b.p. 170 C flash pt. 93 C autoignition temp. 410 C ref. index 1.4540 pH 12.1 surf. tens. 48.89 dynes/cm dielec, const. 37.72... 

Hydroxyethyl actoacetate acrylate. See 2-(Acetoacetoxy) ethyl acrylate 2-Hydroxyethylamine P-Hydroxyethylamine. 

SYNS DEANOL DIMETHYLAETHANOLAMIN (GERMAN) DIMETHYLAMINOAETHANOL (GERMAN) DIMETHYLAMINOETHANOL P-DIMETHYLAMINOETHANOL N,N-DIMETHYL-AMINOETHANOL 2-(DIMETHYLAMINO)ETHANOL p-DIMETHYLAMINOETHYL ALCOHOL DLMETHYLETHANOLAMINE N N-DIMETHYL-ETHANOLAiMINE DIMETHYLETHANOLAMINE (DOT) N,N-DIMETHYL-2-HYDROXYETHYLAMINE ... 

From the antipode (lR,2S)-l,2-diphenyl-2-hydroxyethylamine is obtained the corresponding enantiomer ethyl (l R,2 S)-N-(l, 2 -diphenyl-2 -hydroxyethyl)-glycinate. mp 127-128°C, [a]p -24.4 (c 5.5, CHjCy. This series, also performed in duplicate, provides yields of 29.2 g and 29.5 g (average yield 84%). 

Dinitro-l, 3-bis( p-bydroxyethylamino)-benzene orn-yel ndls (from ale), having a bitter taste, mp 211° practically insol in eth, petf eth, chlf, benz Sc toluene si sol in w, was prepd by treating an alcoholic Soln of l,3-dichloro-4,6-dinitrobenzene with 4 equivs of j3-hydroxyethylamine (Ref 3). 

P-Aminoethyl alcohol colamine ethylolamine P-hydroxy-ethylamine 2-hydroxyethylamine. 

Wood S, Wen PH, Zhang J, Zhu L, Luo Y, Babu-Khan S et al (2012) Establishing the relationship between in vitro potency, pharmacokinetic, and pharmacodynamic parameters in a series of orally available, hydroxyethylamine-derived P-secretase inhibitors. J Pharmacol Exp Ther 343 460 67... 

Anhydrous piperazine is a white solid which is obtained as leaflets when crystallised from alcohol, m.p. 106°C (b.p. 145-146 C). Piperazine may be prepared by several methods [40], However, industrially it is best prepared by cyclodehydration of 2-hydroxyethylamine (34) or N-(2-aminoethyl)-2-hydroxyethylamine (35) at high temperatures in the presence of a catalyst like Ra-Ni and habdes of Zn, Fe, A1 or Mg [41-43]. Catalytic deamination of diethylenetriamine (36) in the presence of Ra-Ni catalyst in an autoclave at 150°C also gives piperazine. Another useful method to prepare piperazine involves reduction of pyrazine (37) by sodium and ethanol [40] (Scheme 1). 

Cyclodehydration of a /J-hydroxyethylamine group to a neighbouring ring-nitrogen is induced by PPA (p. S37), but phosphorus oxychloride may be a more efficient reagent and was recently used in the synthesis of the first member of a tetracyclic ring system. 

Amlno-2-methylethanol 2-Aminopropanol 2-Amlno-1-propanol 2-Amlnopropan-1-ol EINECS 201-156-4 EINECS 228-207-3 1-Hydroxy-2-aminopropane 1-Methyl-2-hydroxyethylamine NSC 1360 p-Propanol-amine 1-Propanol, 2-amino- MIPA Aliphatic amine. Solubilizer, neutralizer, emulsifying agent ptasticizers, insecticides. Liquid bpn 173-176 soluble in H2O, organic solvents. Ashland BASF Corp. Mitsui Toatsu. 

Synonyms/Trade Names 2-Aminoethanol, p-Aminoethyl alcohol, Ethylolamine, 2-Hydroxyethylamine,... 

N, N-Dimethylaminoethanol P-Dimethylaminoethyl alcohol N,N-Dim-ethyl ethanolamine N,N-Dimethyl-2-hydroxyethylamine DMAE DMEA Ethanol, 2-(dimethylamino)- P-Hydroxyethyidimethylamine... 

A mixture of polyphosphoric acid and POCI3 added to a soln. of 2 g. N-acetyl-a,j -diphenyl-/ -hydroxyethylamine in dry toluene, and refluxed with stirring until HCl-evolution ceases after ca. 5 hrs. 1 g. l-methyl-4-phenylisoquinoline. F. e. s. N. L. Dutta, M. S. Wadia, and A. P. Bindra, J. Indian Chem. Soc. 48, 873 (1971). 

By the same token, reaction with participation by one water molecule will be relatively slow when both reactive sites are firmly hydrated. In that case, we may observe fast reaction with participation of two water molecules. However, in no case is reaction with solvent participation expected to be fast unless the conformation of the firmly bound solvent molecule is favourable for proton transfer. Thus, the relatively small values of the rate constants for reaction of tris- -hydroxyethylamine compared to triethylamine in water (Table 1) and of N,N-diethyl-w-toluidine compared to p-toluidine in methanol (Table 2) suggest that polar substituents or centres of van der Waals attraction can modify the hydrogen-bonded structure in the solvation shell. 

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