Hydroxy ethylamine

N-Ethy I-N-2-hydroxy ethylamine Hydroxychloroquine sulfate Ethyl a-hydroxyisobutyrate Trimethadione Ethyl iodide... 

MONO- ETHANOLAMINE 2-Aminoethanol, beta-Amlnoethyl alcohol, Ethanolaiuine, 2-Hydroxy-ethylamine Corrosive Material, III 2 2 0... 

P-Aminoethyl alcohol colamine ethylolamine P-hydroxy-ethylamine 2-hydroxyethylamine. 

METHYL-2-HYDROXY-ETHYLAMINE (78-91-1) Combustible liquid (flash point 145°F/63°C). Violent reaction with strong oxidizers, strong acids, isopropyl percarbonate, ni-trosyl perchlorate. Incompatible with aldehydes, nonoxidizing mineral acids, cellulose nitrate (of high surface area), cresols, isocyanates, nitrates, nitric acid, organic anhydrides, phenols, sulfuric acid. Attacks aluminum, copper, zinc, or their alloys and galvanized steel. 

Ethanolamine ammonia lyase (EAL) converts ethanolamine (2-hydroxy-ethylamine) to acetaldehyde, with the loss of ammonia. The cobamide bovmd to the enzyme of Clostridium sp. was identified as a pseudocoenzyme B12 (37) [221] but a range of other adenosyl-cobamides are accepted as cofactors. The active enzyme is multimeric, has an apparent molecular mass of about 560-600 kDa, but further studies are much less advanced with EAL than those of the AdoCbl-dependent enzymes described above. From ESR studies [222], and the fact that the cobalamin binding motif (Gly-X-X-His-X-Asp) is absent [223], EAL was concluded to be a base-on B -dependent... 

Gueto-Tettay C, Drosos JC, Vivas-Reyes R (2011) Quantum mechanics study of the hydroxy-ethylamines-BACE-1 active site interaction energies. J Comp Aid Mol Des 25(6) 583-597. doi 10.1007/sl0822-011-9443-z... 

Different kinetic behavior was observed when secondary hydroxy-alkylic amines, methyl-2-hydroxyethylamine and butyl-2-hydroxy-ethylamine, were employed as nucleophiles. Autoacceleration appeared in dioxane for both secondary amines however, normal second order kinetics were followed in DMF when the nucleophile is methyl-2-hydroxyethylamine which has less bulky substituents. In the reaction of butyl-2-hydroxyethylamine with CMPS in DMF, rate retardation began when the conversion reached about 75% owing to the steric hindance of the bulky butyl groupThus the sensitivity of the rate profiles to reaction media and nucleophile structure complicates assessment of "polymeric effects". 

Chem. Desaip. N-alkyl tallow N,N bis hydroxy ethylamine and tallow alkyl amines... 

An ethereal soln. of p-methoxybenzaldehyde cyanohydrin added dropwise at 0° to a slurry of LiAlH4 in the same solvent, stirring continued 5-6 hrs. at room temp., then refluxed 4-5 hrs. on a water bath -p-methoxyphenyl-/ -hydroxy-ethylamine. Y 80%. F. e., also in tetrahydrofuran, s. N. Adityachaudhury and A. Ghatterjee, J. Indian Ghem. Soc. 36, 585 (1959). 

The molecular modelling approach, taking into account the pyruvate—cinchona alkaloid interaction and the steric constraints imposed by the adsorption on the platinum surface, leads to a reasonable explanation for the enantio-differentiation of this system. Although the prediction of the complex formed between the methyl pyruvate and the cinchona modifiers have been made for an ideal case (solvent effects and a quantum description of the interaction with the platinum surface atoms were not considered), this approach proved to be very helpful in the search of new modifiers. The search strategy, which included a systematic reduction of the cinchona alkaloid structure to the essential functional parts and validation of the steric constraints imposed to the interaction complex between modifier and methyl pyruvate by means of molecular modelling, indicated that simple chiral aminoalcohols should be promising substitutes for cinchona alkaloid modifiers. Using the Sharpless symmetric dihydroxylation as a key step, a series of enantiomerically pure 2-hydroxy-2-aryl-ethylamines... 

DCM (anhydrous), DMSO (anhydrous), triethylamine (99 + %), sulfur trioxide-pyridine complex, DMA (anhydrous), potassium tert-butoxide (95%), DCE (anhydrous), 2-(4-methoxyphenyl)ethylamine (98 + %), sodium triacetoxy-borohydride (95%), A/A-diisopropylethylamine (99%), p-toluenesulfonyl chloride (99 + %), and trifluoroacetic acid (99 + %) were obtained from Aldrich Chemical Company, Inc. 4-Hydroxy-2-methoxybenzaldehyde (>98%) was obtained from Fluka Chemie, AG. 

Note According to Merck and Co., the potency of the hydroxy version of phenylisopropylamine is nearly as great as the non-hydroxy version, thus the above reduction may be omitted if you find the phenylisopropyl-hydroxylamine high enjoyable. Hydroxy methylenedioxyphen-ethylamine has been reported to be a very pleasant high. 

Solid lactones or cyclic carbonates form linear hydroxy amides upon reaction with gaseous ammonia, methylamine, or ethylamine. For example, the compounds 277a-c and (ketonized) 279a-c are quantitatively formed at 0 °C and room temperature, respectively, without melting [12] (Scheme 39). 

Benzylische Acyloxy-Gruppen wie z.B. in 4,7-Diacetoxy-6-methoxy-2-methyl-l,2,3,4-te-trahydro-isochinolin werden bei der Reaktion mit primaren Aminen unter milden Bedin-gungen durch eine Alkylamino- Oder Arylamino-Gruppe ersetzt gleichzeitig wird die zwei-te Acetoxy-Gruppe im Molekul hydrolysiert, so daB man mit Ethylamin bzw. Anilin 4-Ethylamino-7-hydroxy-6-methoxy-2-methyl- (82%) bzw. 4-Anilino-7-hydroxy-6-meth-oxy-2-methyl-l,2,3,4-tetrahydro-isochinolin (66%) erhalt1. 

A similar example is the ring expansion of cyclobutanone via l-tris(methylsulfanyl)methyl-cyclobutanol (6) to 2,2-bis(methylsulfanyl)cyclopentanone (7).43 The use of Af,A-diisopropyl-ethylamine is unneccessary in this reaction as the hydroxy group has already been deprotonated with butyllithium. Further examples of this type of reaction can be found in refs 43 and 44. 

The coordination process may either stabilize or destabilize aromatic Schiff bases. If nickel (II) salts are added to ammoniacal solutions of salicylaldehyde, the precipitate obtained is the inner complex salt of nickel (II) and salicylaldimine (61). If beryllium chloride is added to the Schiff base derived from 2-hydroxy-l-naphthaldehyde and ethylamine, however, the Schiff base is decomposed and the inner complex of beryllium (II) and 2-hydroxy-1-naphthaldehyde is obtained (59). Here the strength of the coordinate bonds formed with the metal seems to determine which complex will be formed. 

Oxidation of fi-(4-Hydroxy-3-methoxyphenyl)ethylamines The j3-(4-hydroxy-3-methoxyphenyl)ethylamines [i.e. the catecholamine 03-methyl ethers, metanephrine (18) and normetanephrine (19)] are known to be among the major in vivo metabolites of... 

Another total synthesis of sufentanil has been described the cyclization of 2-(2-thienyl)ethylamine with allyl-trimethylsilane and formaldehyde gives 4-hydroxy-1-[2-(2-thienyl)ethyl]piperidine, which is oxidized with oxalyl chloride in DMSO/dichloromethane to 1-[2-(2-thienyl) ethyl]piperidin-4-one. The epoxidation of this compound by means of trimethylsulfonium iodide and the sodium salt of DMSO yields the spiro-epoxide, which is opened with... 

An attempt to utilize this conversion of amines into aldehydes in an isoquinoline synthesis was not successful.439 Instead, reaction between 2-(3,4-dimethoxyphenyl)ethylamine and isatin afforded only the spiro compound 150.439 Reaction between isatin and 2-(3-hydroxy-4-methoxyphenyl)ethylamine gave a mixture of two spiro compounds, while a reaction of isatin, this amine, and benzylamine gave 6-hydroxy-7-methoxy-l-phenyl-1,2,3,4-tetrahydroisoquinoline.439... 

The elimination of water from (3-hydroxy-a-amino acid derivatives 28 is a particularly valuable method for the synthesis of DHAs 29, when the corresponding hydroxy compounds are readily accessible, such as, those of Ser, Thr and Ser( 3-Ph). 93 Some of the reagents recommended for the elimination of water are disuccinimidyl carbonate, 9495 l,l -carbonyl-diimidazole, 96 or a base and acetic anhydride. 97 Reaction of l,l -carbonyldiimidazole with arylidene Ser esters gives the corresponding DHA derivatives. 98 In the, presence of tri-ethylamine with terminally protected Ser and Thr residues in an inert solvent this reagent affords the AAla and AzAbu acid derivatives in good yields 96 (Scheme 10). This is perhaps one of the simplest and cleanest ways to prepare AAla and AAbu derivatives. 

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