DIMETHYL AMINOETHANOL

The crude iodinated acid was then dissolved in 500 ml of 95% alcohol, 10 g of dimethyl-aminoethanol was added, the solution was decolorized with activated charcoal and filtered at 70°C. After keeping the filtrate for several hours at 5°C, the heavy crystalline precipitate which formed was collected by filtration and washed with acetone. The mother liquors were concentrated to 150 ml and cooled to give a second crop which was further purified by recrystallization from 50 ml of 95% alcohol. In this way a total of 36.0 g of dimethyl-aminoethanol salt of dextro-/3-(3,5-diiodo-4-hydroxy)-o-phenylpropionic acid, MP 151° to 153°C, was obtained. The melting point of the dimethylaminoethanol salt of unresolved /3-(3,5-diiodo-4-hydroxy)-o-phenylpropionic acid was 142° to 144°C. 

Roulier et al. reported a sensitive and specific method for the measurement of choline and hydrogen peroxide in sea-water [45]. Choline was oxidized by choline oxidase to produce betaine and H202. The latter was used with horse-radish peroxidase to oxidize hydro-xyphenyl-propionic acid to produce a fluorescent diphenol end product. The resulting fluorescence at 410 nm (excitation at 320 nm) was proportional to the amount of H202, and could thus be used to measure the amount of choline present in the sample. Only 2-dimethyl aminoethanol interfered. The method was optimized, and used to determine 0 15 nM choline in coastal sea-water. 

In a dry 1-1. flask fitted with a sealed mechanical stirrer, an efficient reflux condenser, and a 500-ml. dropping funnel is placed 290 g. (2.44 moles) of thionyl chloride (Note 1). The reaction flask must be cooled in an ice bath throughout the entire period of operation, as the reaction is very exothermic. /3-Dimethyl-aminoethanol (210 g., 2.35 moles) (Note 2) is added dropwise through the funnel to the cooled thionyl chloride (Note 3) over a period of an hour, during which time there is a copious evolution of sulfur dioxide (Note 4). After all the /3-dimethylamino-ethanol has been added, the ice bath is removed and the reaction mixture is stirred for another hour (Note 5). The temperature of the mixture is 35 50°. At this point the reaction mixture... 

SYNS DEANOL DIMETHYLAETHANOLAMIN (GERMAN) DIMETHYLAMINOAETHANOL (GERMAN) DIMETHYLAMINOETHANOL P-DIMETHYLAMINOETHANOL N,N-DIMETHYL-AMINOETHANOL 2-(DIMETHYLAMINO)ETHANOL p-DIMETHYLAMINOETHYL ALCOHOL DLMETHYLETHANOLAMINE N N-DIMETHYL-ETHANOLAiMINE DIMETHYLETHANOLAMINE (DOT) N,N-DIMETHYL-2-HYDROXYETHYLAMINE ... 

In addition 3-methylmorphol was condensed with /kdimethylamino-ethyl chloride to give 3-methyl-4-(/3-dimethylaminoethyl)-morphol [xxxvn], which was unaffected by sodium ethoxide at 150° C., but was degraded to 3-methyl-4-acetylmorphol [xxvn, R = Ac] and /S-dimethyl-aminoethanol on heating with acetic anhydride, and to morphol [xxi], /3-dimethylaminoethanol, and tetramethylethylenediamine on heating with hydrogen chloride [52],... 

Methoxy-4 8-diacetoxyphenanthrene [Lxxxm]. /3-Dimethyl-aminoethanol and [Lxxxm] are formed when i/r-codeinone [lxxxiv] is heated with acetic anhydride, but the main product of this reaction is triacetylthebenine [lxxxv, R = Ac] [89]. i/r-Codeinone methiodide and ethanol at 160° C. give 3-methoxy-4 8-dihydroxyphenanthrene [89-90], which on methylation affords 3 4 8-trimethoxyphenanthrene [90], identical with an authentic specimen prepared in the usual way from 2-nitroveratric aldehyde and 2-methoxyphenylacetic acid [67]. In this way the location of the hydroxyl group in i/r-codeine and allo- -codeine, at C-8, was proved. 

This paper reviews and extends our work on structural characterization of the extracellular ethanolamine-/N,N -dimethyl-aminoethanol-containing peptidophosphogalactomannan of P. 

Related Reagents. t-Butoxide Methyllithium Tungsten(VI) Chloride-n-Butyllithium n-ButyUithium-Lithium Dimethyl-aminoethanol s-Butyllithium and r-Butyllithium. 

Fig. 3. The formation of radioactive pho phatidyl-2-dimethylaniinoethanol in the brain 4 to 5 hours after the injection of the hydrochloride of the base (150 mg/kg body weight) and 12 me P 2-orthophosphate/kg body weight into a 50 gm rat. The total brain lipids were fractionated on a column of dumina, and phospholipids were eluted as indicated in the figure. Continuous line rat injected with 2-dimethyl-aminoethanol (DMAE) interrupted line control (P only). (Reproduced from Ansell (1964) by permission of the publishers.)...

When fed in place of choline it was observed that dimethylamino-ethanol prevented fatty liver but led to poor growth on a homocystine diet, whereas the monomethyl compound was quite toxic. The interpretation to be placed on this result is that the di- and monomethyl-aminoethanols can be converted to choline by being methylated, but cannot serve as methyl donors themselves. The conversion of ethanol-amine to choline by successive methylation steps has received support from a study of choline synthesis in cholineless mutants of Wewrospora. Monomethylaminoethanol was isolated from the culture media of one cholineless mutant, and it was found to support the growth of a second cholineless mutant. This is evidence that the monomethyl derivative is an intermediate in the synthesis of choline by Neurospora. Dimethyl-aminoethanol promotes the growth of both strains. 

Water reducible, or water thinnable, synthetic polymers are usually acidic, typically containing carboxyl groups built into the polymer chain. These require neutralisation with a base, with ammonia, triethylamine, dimethyl aminoethanol being typical, and often the use of cosolvents, such as glycol ethers, to produce complete compatibility with water. 

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