P gene

Figure 15.21 T-cell receptor cx and p genes undergo rearrangments much like immunoglobln genes (see Figure 15.5).

FIGURE 18-9 Several mechanisms through which the substance P gene gives rise to different bioactive peptides in different neurons. Alternative splicing of mRNA leads to translation of distinct precursors, and subsequent processing leads to unique mature peptides. PPT, pre-protachykinin. (Adapted from reference [16].)... 

Mombaerts, P. Genes and ligands for odorant, vomeronasal and taste receptors. Nat. Rev. Neurosci. 5 263-278, 2004. 

Clarke, P.A., ter Poele, R., Wooster, R., and Workman, P., Gene expression microarray analysis in cancer biology, pharmacology, and drug development progress and potential, Biochem. Pharmacol. 62, 1311-1336, 2001. 

Grotewold, E., Athma, P., and Peterson, T., Alternatively spliced products of the maize P gene encode proteins with homology to the DNA-binding domain of Myb-like transcription factors. Proc. Natl Acad. Sci. USA, 88, 4587, 1991. 

The maize P gene has been implicated in the regulation of phlobaphene synthesis. Phlobaphenes are red pigments that accumulate in the pericarp of the maize kernel, as well as various other parts of the plant, including the... 

Grotewold, E., Drummond, B. J., Boen, B., and Peterson, T., 1994, The myh -homologous P gene controls phlobaphene pigmentation in maize floral organs by directly activating a flavonoid biosynthetic gene subset, Cell 76 543-553. 

Cory, S., Adams, J.M., Kemp, D.J. (1980). Somatic rearrangements forming active immunoglobulin p genes in B and T lymphoid cell lines. Proc. Natl. Acad. Sci. USA 77, 4943-4947. 

Early, P., Rogers, J., Davis, M., Calame, K., Bond, M., Wall, R., Hood, L. (1980b). T vo mRNAs can be produced from a single immunoglobulin p gene by alternative RNA processing pathways. Cell 20,313-319. 

Malissen, M., Trucy, J., Jouvin-Marche, E., Cazenave, P.-A., Scollay, R., Malissen, B. (1992). Regulation of TCR a and P gene allelic exclusion during T-cell development Immunology Today 13,315-322. 

Zanta, M. A., Belguise-Valladier, P, and Behr, J. P. Gene delivery A single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus. Proc. Natl. Acad. Sci. USA 96(l) 91-96. 1999. 

Fletcher, S.T., Baker, V.A., Fentem, J.H., Basketter, D.A., and Kelsell, D.P. Gene expression analysis of EpiDerm following exposure to SLS using cDNA microarrays. Toxicol. In Vitro 2001 15 393-398. 

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