P-glycoprotein gene

N. M. T. Van der Lugt, M. A. Van Roon et al, Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease. Cell 1993, 75, 451-462. 

S. J., Helgason, C. D., Ackerley, C., Phillips, M. J., Ling, V., Targeted inactivation of sister of P-glycoprotein gene (spgp) in mice results in nonprogressive but persistent intrahepatic cholestasis, Proc. Natl. Acad. Sci. USA 2001, 98, 2011-2016. 

C. A. A. M., van der Valk, M. A., RobanusMandaag, E. C., Borst, P., Disruption of the mouse mdrla P-glycoprotein gene leads to a deficiency in the blood brain barrier and to increased sensitivity to drugs, Cell 1994, 77, 491-502. 

Smith AJ, de Vree JM, Ottenhoff R, Oude Elferink RP, Schinkel AH, Borst P. Hepatocyte-specific expression of the human MDR3 P-glycoprotein gene restores the biliary phosphatidylcholine excretion absent in Mdr2 (-/-) mice. Hepatology 1998 28(2) 530-536. 

Saito, T., Zhang, Z. J., Ohtsubo, T., et al. (2001) Homozygous disruption of the mdrla P-glycoprotein gene affects blood-nerve barrier function in mice administered with neurotoxic drugs. Acta Otolaryngol. 121, 735-742. 

Chaudhary PM, Roninson IB (1992) Activation of MDRl (P-glycoprotein) gene expression in human cells by protein kinase C agonists. Oncology Research 4 281-290... 

Uhr M, Grauer MT (2003) abcblab P-glycoprotein is involved in the uptake of citalopram and trimipramine into the brain of mice. J Psychiatr Res 37 179-185 Uhr M, Sleekier T, Yassouridis A, Holsboer F (2000) Penetration of amitriptyhne, but not of fluoxetine, into brain is enhanced in mice with blood-brain barrier deficiency due to mdrla P-glycoprotein gene disruption. Nemopsychopharmacology 22 380-387... 

Gruol, D.J., and S. Bourgeois. 1994. Expression of the mdrl P-glycoprotein gene A mechanism of escape from glucocorticoid-induced apoptosis. Biochem Cell Biol 72 561. 

Uhr, M., et al. 2000. Penetration of amitriptyline, but not of fluoxetine, into brain is enhanced in mice with blood-brain barrier deficiency due to mdrla P-glycoprotein gene disruption. Neuropsychopharmacology 22 380. 

Dagenais C, Zong J, Ducharme J, et al. Effect of mdrla P-glycoprotein gene disruption, gender, and substrate concentration on brain uptake of selected compounds. Pharm Res 2001 18 957-963. 

Chen CJ, Chin JE, Ueda K, et al. Internal duplication and homology with bacterial transport proteins in the mdrl (P-glycoprotein) gene from multidrug-resistant human cells. Cell 1986 47(3) 381-389. 

Deuchars KL, Duthie M, Ling V. Identification of distinct P-glycoprotein gene sequences in rat. Biochim Biophys Acta 1992 1130(2) 157—165. 

Childs S, Ling V. Duplication and evolution of the P-glycoprotein genes in pig. Biochim Biophys Acta 1996 1307(2) 205-212. 

Borst P, Schinkel AH. What have we learnt thus far from mice with disrupted P-glycoprotein genes Eur J Cancer 1996 32A(6) 985-990. 

Groen AK, Van Wijland MJ, Frederiks WM, et al. Regulation of protein secretion into bile studies in mice with a disrupted mdr2 p-glycoprotein gene. Gastroenterology 1995 109(6) 1997-2006. 

Endicott JA, Sarangi F, Ling V. Complete cDNA sequences encoding the Chinese hamster P-glycoprotein gene family. DNA Seq 1991 2(2) 89-101. 

Choi KH, Chen CJ, Kriegler M, Roninson IB. An altered pattern of cross-resistance in multidrug-resistant human cells results from spontaneous mutations in the mdrl (P-glycoprotein) gene. Cell 1988 53 519-29. 

Kioka N, Tsubota J, Kakehi Y, Komano T, Gottesman MM, Pastan I et al. P-glycoprotein gene (MDRl) cDNA from human adrenal Normal P-glycoprotein carries Glyl85 with an altered pattern of multidrug resistance. Biochem Biophys Res Commun 1989 162 224-31. 

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