P388 mouse leukaemia

KB = human epidermoid earcinoma cells HeLa = human eervieal carcinoma cells H210 = murine lymphoma cells P388 = mouse leukaemia cells... 

Konovalova et al. (2003) HMOorNMO/ cyclophos- phamide (CPA) Mouse leukaemia (p388) Mouse lung carcinoma (LL) Animal survival increased from 60% to 100% by co-injection of NMO (1 mg) Tumour regrowth completely inhibited for 40 d in 50% of animals (NMO 1 mg/kg x3). 

Some inhibitory activity of gossypol against mouse mammary adenocarcinoma 755 and borderline activity against leukaemia P388 were reported [323, 324], The effective dose range of gossypol is rather narrow because of toxicity [324]. Gossypol has recently been found to be a specific inhibitor of DNA polymerase a [325], a major enzyme involved in DNA replication. This compound may also interfere with the DNA repair process [325]. 

A pronounced effect in vivo was also observed after injection of either formaldehyde-treated RNA or polyadenylic acid into the peritoneal cavity of the mouse where the murine leukaemia cell line (P388) was growing as an ascitic tumour [12]. 

Fig. 4. The comparative cytotoxicity (top clonogenic assay, 2 h treatment of B16 mouse melanoma cells) and antitumour activity (P388 leukaemia, ILS at the maximum tolerated dose) of gold(I) phosphine complexes ( ) EtsPAuSR where SR = SGlu (P-D-thioglucose), SGlu(Ac)4 (tetraacetyl-P-D-thioglucose) or TM (thiomalate), and the non-phosphine analogues [AuSR] (O). Data from Ref. 55...

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