Oxidative stress osteoporosis

Oxidative stress is now recognized as an important etiological factor in the causation of several chronic diseases including cancer, cardiovascular diseases, osteoporosis, and diabetes. Antioxidants play an important role in mitigating the damaging effects of oxidative stress on cells. Lycopene, a carotenoid antioxidant, has received considerable scientific interest in recent years. Epidemiological, tissue culture, and animal studies provide... 

Evidence associating oxidative stress and antioxidants with osteoporosis... 

Low bone density is also associated with oxidative stress in lower species. Thus, in ovariectomized rats melatonin has a bone-protective effect, which depends in part on its free radical-scavenging properties (Cardinali et al., 2003). A mouse model that has been used to study the role of ROS in age-related disorders including osteoporosis is the accelerated mouse-senescence-prone P/2 (SAM-P/2) that generates increased oxygen radicals (Hosokawa, 2002 Udagawa, 2002). This model could be very useful in studying the role of lycopene in osteoporosis. 

Rao, L.G., Collins, E.S., Josse, R.G., Strauss, A., and Rao, A.V. 2005. Lycopene consumption significantly decreases oxidative stress and bone resorption marker in postmenopausal women at risk of osteoporosis. Joint Meeting of the ECTS and IBMS June 25-29. Geneva, Switzerland. 

Varanasi, S.S., Francis, R.M., Berger, C.E., Papiha, S.S., and Datta, H.K. 1999. Mitochondrial DNA deletion associated oxidative stress and severe male osteoporosis. Osteoporos. Int. 10, 143-149. 

Adipocytes asthma diabetes obesity rheumatoid arthritis Osteoporosis otitis media oxidative stress periodontal disease... 

Osteoclast activation and mononuclear cell infiltration are generally associated with bone loss. The consumption of black tea effectively reduced osteoclast activation and oxidative stress mononuclear layer cells in rats, thus restoring skeletal health [121]. Osteoporosis is a familiar problem linked with chronic liver disease [122]. Tea compounds, including TFS and EGCG, suppressed the formation and differentiation of osteoclasts by decreasing their enz5miatic activities and the gene ex-... 

Coconut oil improves the ability of the body to absorb important minerals. This includes calcium and magnesium which are necessary for the development of bones and also reduces the oxidative stress within the bone, which may prevent structural damage in osteoporotic bone. Thus, coconut oil is very useful to women who are prone to osteoporosis (a disease of bone that can cause fractures) after middle age (Hegde, 2006 Hegde, 2009). 

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