Rheumatoid arthritis osteoporosis and

Many disorders benefit from exercise (Pederson Saltin, 2005). These include asthma, cancer, chronic heart failure, coronary artery disease, chronic obstructive pulmonary disease (COPD), depression, type 1 diabetes melUtus, type 2 diabetes melUtus, hypertension, intermittent claudication, osteoarthritis, osteoporosis, rheumatoid arthritis and obesity. 

An inhibitor of osteoclast differentiation and / or function is expected to be useful for treatment of bone lytic diseases such as osteoporosis, rheumatoid arthritis, and tumor metastasis into bone. Paenol inhibits RANKL-induced osteoclastogenesis by inhibiting ERK, p38, and NF-kB pathway (Tsai et ah, 2008). S)unbioimine (Fig. 32.2A) from the symbiotic marine dinoflagellate Symbiodinium sp. exhibits inhibitory effect on osteoclast differentiation (Kita et ah, 2004). 

Topical Mg in gel (Epsom gel) or solution form has anecdotal evidence for use in minor myalgias and arthalgias in osteoarthritis, osteoporosis, rheumatoid arthritis and fibromyalgia. 

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