Oxidative stress modulation

Talati, M., Meyrick, B., Peebles, R.S., Jr., Davies, S.S., Dworski, R., Mernaugh, R., Mitchell, D., Boothby, M., Roberts, L.J., and Sheller, J.R. Oxidant stress modulates murine allergic airway responses. Free Radic Biol Med 40 (2006) 1210-1219. 

Inhibition of oxidative stress modulation of signal transduction and gene expression - ... 

Oettl, K. and Reibnegger, G., Pteridine derivatives as modulators of oxidative stress, Curr. Drug Metab., 3, 203, 2002. 

Cemeli E, ED Wagner, D Anderson, SD Richardson, MI Plewa (2006) Modulation of the cytoxicity and geno-toxicity of the drinking water disinfection byproduct iodoacetic acid by suppressors of oxidative stress. Environ Sci Technol 40 1878-1883. 

Oxidant Stress and the Heart Modulation of Ion Transport Mechanisms During Ischaemia and... 

If cellular redox state, determined by the glutathione status of the heart, plays a role in the modulation of ion transporter activity in cardiac tissue, it is important to identify possible mechanisms by which these effects are mediated. Protein S-,thiolation is a process that was originally used to describe the formation of adducts of proteins with low molecular thiols such as glutathione (Miller etal., 1990). In view of the significant alterations of cardiac glutathione status (GSH and GSSG) and ion-transporter activity during oxidant stress, the process of S-thiolation may be responsible for modifications of protein structure and function. 

The natural endogenous physiological antioxidant systems for controUing the potentially injurious elFects of environmentally exacerbated oxidative stress, may be modulated by a number of various nutritional and pharmacological supplementary interventions. 

Numerous studies have demonstrated that degradation products of (3-carotene exhibit deleterious effects in cellular systems (Alija et al., 2004, 2006 Hurst et al., 2005 Salerno et al., 2005 Siems et al., 2003). A mixture of (3-carotene degradation products exerts pro-apoptotic effects and cytotoxicity to human neutrophils (Salerno et al., 2005 Siems et al., 2003), and enhances the geno-toxic effects of oxidative stress in primary rat hepatocytes (Alija et al., 2004, 2006), as well as dramatically reduces mitochondrial activity in a human leukaemic cell line, K562, and RPE 28 SV4 cell line derived from stably transformed fetal human retinal pigmented epithelial cells (Hurst et al., 2005). As a result of degradation or enzymatic cleavage of (3-carotene, retinoids are formed, which are powerful modulators of cell proliferation, differentiation, and apoptosis (Blomhoff and Blomhoff, 2006). 

Altogether, there is strong evidence that carotenoids can exert multiple effects via modulation of signaling pathways. Because oxidative stress can easily degrade carotenoids, it is not enough to investigate the effects of intact carotenoids, but it is necessary to elucidate the effects of their degradation products as well. 

Herzog, E. et al. (2009) Dispersion medium modulates oxidative stress response of human lung epithelial cells upon exposure to carbon nanomaterial samples. Toxicology and Applied Pharmacology, 236 (3), 276-281. 

It has been suggested that tamoxifen, one of the most effective therapeutic and chemopreventive agent for breast cancer, modulates protein kinase C through oxidative stress in breast cancer cells [194], Unfortunately, most breast cancers initially responsive to tamoxifen treatment later become resistant. Schiff et al. [195] suggested that the conversion of breast tumors to a tamoxifen-resistant phenotype is associated with oxidative stress and depends on significantly enhanced SOD activity in tumors. 

Baumer AT, Wassmann S, Ahlbory K, Strehlow K, Muller C, Sauer H, Bohm M, Nick-enig G (2001) Reduction of oxidative stress and AT 1 receptor expression by the selective oestrogen receptor modulator idoxifene. Br J Pharmacol 134 579-584... 

Chandra, J., Samah, A., and Orrenius, S., 2000, Triggering and modulation of apoptosis by oxidative stress. Free Radical Biol. Med. 29 323-333. 

Decker P, Muller S (2002) Modulating poly (ADP-ribose) polymerase activity potential for the prevention and therapy of pathogenic situations involving DNA damage and oxidative stress. Curr Pharm Biotechnol 3 275-283... 

Since flavonoids are able to bind to the BDZ binding site of the GABA-A receptor, they might well interact with the BDZ binding site of the mitochondrial permeability transition protein, thereby modulating oxidative stress-induced apoptosis. ... 

---