Ovulation anovulatory infertility

In females, menotrophins and hCG are used for the treatment of anovulatory infertility. This condition is due to insufficient endogenous gonadotrophin production. Menotrophin is administered to stimulate follicular maturation, with subsequent administration of hCG to promote ovulation and corpus luteum formation. Mating at this point should lead to fertilization. 

Indications Development of multiple follicles in ovulatory patients and the induction of ovulation and pregnancy in anovulatory infertile patients... 

B. Indications and nse Follistim is indicated for the development of multiple follicles in ovulatory patients participating in an assisted reproductive technology program. It is also indicated for the induction of ovulation and pregnancy in anovulatory infertile patients in whom the cause of infertility is functional and not due to primary ovarian failure. 

Z2. Zarate, A., Canales, E., Schally, A. V., Ayala-Valdes, L., and Kastin, A. J., Successful induction of ovulation with synthetic luteinizing hormone-releasing hormone in anovulatory infertility. Fert. SterU. 23, 672-674 (1972). 

Female infertility this can be due to abnormalities in ovulation or abnormal hormone production or ovaries. There may be anatomical defects in the Fallopian tubes or uterus, production of abnormal cervical mucus or an immunological problem. In young women failure of menstruation and anovulatory cycles can be triggered by many external factors, including rapid weight loss. Since the number of ovarian follicles capable of maturation is fixed at birth, few remain as women approach the menopause. The oestrogen levels also fall and ovaries lose their responsiveness to FSH and LH, and so ovulation and fertility is impaired in older women. 

Clomiphene is an ovulation stimulant that induces ovulation in selected anovulatory women. It is indicated in the treatment of ovulatory failure in women desiring pregnancy when the partner is fertile and potent. Clomiphene (Clomid, serophene, others) is approved for the treatment of infertility in anovulatory women, and fulvestrant is used for the treatment of breast cancer in women with disease progression after tamoxifen. 

Like LH, hCG stimulates the production of testosterone by the testes therefore, it is used in treating male hypogonadism and prepubertal cryptorchidism in young males (age, 4-9 years), in whom it stimulates testicular descent. In treating infertility caused by pituitary dysfunction, hCG, in combination with menotropins (as discussed previously) or clomiphene, can induce ovulation and pregnancy in anovulatory females. This hCG, which is of natural origin, is purified from the urine of pregnant women. 

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