Drug overdose

The various barbiturates differ m the time required for the onset of sleep and m the duration of their effects All the barbiturates must be used only m strict accordance with instructions to avoid potentially lethal overdoses Drug dependence m some mdi viduals IS also a problem... 

D Ineffective Airway Clearance related to administration of a narcotic (specify overdose, drug idiosyncrasy, or other cause)... 

Salhanick SD, Shannon MW. Management of calcium channel antagonist overdose. Drug Saf 2003 26(2) 65-79. 

The book set in the entertainment world reflected society s acceptance of those drugs. Susann wrote about what led the women to take drugs and the effects of drug abuse, including overdose. Drugs changed one character s personality, and she was hospitalized to withdraw from drugs. 

Davis LE, Becher MW, Tlomak W, Benson BE, Lee RR, Fisher EC. Persistent choreoathetosis in a fatal olanzapine overdose drug kinetics, neuroimaging, and neuropathology. Am J Psychiatry 2005 162 28-33. 

Perry HE, Wright RO, Shannon MW, Woolf AD. Baclofen overdose drug experimentation in a group of adolescents. Pediatrics 1998 101(6) 1045-8. 

Peterson CD, Leeder JS, and Sterner S (1984) Glucagon therapy for B-blocker overdose. Drug Intelligence Clinical Pharmacy 18 394-398. 

A healthcare provider can purposely reduce the elimination of medication, thereby increasing the medication s therapeutic effect by administering medication that blocks the excretion of a medication. For example, probenecid blocks excretion of penicillin. In contrast, dialysis can be used to increase the excretion of medication, which is common in certain medication overdoses. Drugs can artificially be excreted through the use of hemodialysis, which is a common treatment in certain drug overdoses. 

Henry JA. Epidemiology and relative toxicity of antidepressant drugs in overdose. Drug Saf 1997 16 374-390. 

Weinbroum AA, Haishon R, Sorkine P. A risk-benefit assessment of flumazenil in the management of benzodiazepine overdose. Drug Saf 1997 17 181-196. 

Nonimmune-mediated idiosyncratic cutaneous reactions can arise from a variety of causes including cumulative toxicity, overdose, drug interactions, and metabolic alterations (Lee and Thompson, 2006). Viral infections can influence and increase the incidence of these cutaneous adverse drug reactions (Svensson et al., 2001 Lee and Thompson, 2006). Pharmacogenomics play an important role in individual susceptibility to adverse skin reactions as well (Lonjou et al., 2006 Tassaneeyakul et al., 2009 Aihara, 2011 KuUcantrakom et al., 2012 Pirmohamed, 2012 Borroni, 2015). 

When these drugs were the only ones implicated, there were nine reports presented to the Food and Drug Administration on Fiorinal and 16 attributed to Fioricet. Serious adverse events associated with Fiorinal were one case of acute overdose and two cases of hepatic and renal failure related to prolonged (more than 10 years) use. Serious adverse effects associated with Fioricet use were one case each of pancreatitis and multisystem illness, three deaths due to overdose, three cases of coma (presumably secondary to overdose), and two cases of other encephalopathy due to overdose. Drug dependence was reported twice. In short, serious adverse events were almost always associated with acute overdose (e.g. ingestion of 30 pills) or prolonged (e.g. 10 years) overuse [8]. 

Frankenfeld JW, Fuller GC, Rhodes CT. 1976. Potential use of hquid membranes for emergency treatment of drug overdose. Drug Dev Commun 2(4-5) 405-419. 

Morimoto Y, Sugibayashi K, Yamagauchi Y, Kato Y. 1979. Detoxication capacity of a multiple (W/O/W) emulsion for the treatment of drug overdose drug extraction into the emulsion in the gastro-intestinal tract of rabbits. Chem Pharm Bull 27(12) 3188-3192. 

Vohra, J. D. (1974) Cardiovascular abnormalities following tricyclic antidepressant drug overdose. Drugs, 7, 323. 

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