Drug overdose valproate

Drug overdose Valproate overdose can mimic brain death [403 ]. 

Drug overdose In a study of 9809 consecutive adults and adolescents with self-poisoning during a 6-month period, there were 474 with non-benzodiazepine antiepileptic drug intoxication [103. The most frequent motivation was intentional intoxication (95.3%). There was no association between antiepileptic drug intoxication and a history of parasuidde, sex, age, or occupation. The most frequent drug involved was carbamazepine ( = 117), followed by phenobarbital ( =77) and sodium valproate ( = 51). 

Drug overdose A 38-year-old man with alcoholism and a history of drug abuse attempted suicide with valproate and developed a... 

Activated charcoal Carbamazepine Lamotrigine Phenobarbital Phenytoin Valproate With some drugs can be exploited to reduce drug concentrations in overdose Sequestration in the gastrointestinal tract... 

After a valproate overdose a 27-year-old man developed seizures, hypernatremia, respiratory failure, metabolic acidosis, liver failure, and bone marrow depression (125). His plasma valproic acid concentration was 1414 pg/ml. Treatment with hemodialysis was effective in enhancing valproic acid clearance, while hemoperfu-sion was relatively less effective, because of saturation of the column. Overall, the half-Ufe of the drug was reduced from over 20 hours before treatment to less than 3 hours during hemodialysis/hemoperfusion drug removal was probably favored by saturation of drug binding to plasma proteins, which resulted in a low unbound fraction (32% at the start of treatment). He was comatose for 5 days but recovered fully thereafter. 

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