Other Signs and Symptoms

A number of other symptoms which have been described cannot be related to ACD with certainty. These include splenomegaly (Brown and Milne 1952), and hepatosplenomegaly and thrombopenia (Wohnlich 1949). The classification 

Abnormal chemical findings in blood are usually restricted to those which result from decreased renal function, such as progressive rise of blood urea nitrogen and uremia. When isosthenuria is established, abnormalities of serum electrolytes may develop. Total serum protein is normal. 

Hematologic findings include mild to moderate anemia, anisocytosis and poikilo-cytosis. In two out of six cases (Fessas et al. 1955) in which white blood cells were differentiated, eosinophilia was observed. 

Thrombocyte count and function is normal with the exception of the case of WoHNLiCH (1949), in which the diagnosis of ACD is not certain. A bleeding tendency or specific abnormalities of the blood clotting mechanism have not been reported. Findings from bone marrow biopsies will be reported in the section on pathology (see page 344). 

Urinary abnormalities consist of proteinuria, cylindruria (hyaline and granular) microhematuria and pyuria. Inability to concentrate may occur simultaneously or may follow such findings after years. 

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EMETICS After file administration of an emetic, file nurse closely observes file patient for signs of shock, respiratory depression, or other signs and symptoms that may be part of file clinical picture of file specific poison or drug that was accidentally or purposely taken. 

Euphoria is the one symptom that most drugs of abuse (with the exception of tobacco) have in common. Other signs and symptoms are specific to the particular drug or class of drugs involved. Table 33-1 lists the psychological/behavioral and... 

Evaluate for an autoimmune disorder if significant dry eyes or other signs and symptoms or family history are present. 

The clinical presentation for IE is quite variable and often nonspecific. A fever is the most frequent and persistent symptom in patients but may be blunted with previous antibiotic use, congestive hear failure, chronic liver or renal failure, or infection caused by a less virulent organism (i.e., subacute disease).3 Other signs and symptoms that also may occur are listed in the Clinical Presentation box with some discussed further in detail below. 

The initial clinical signs and symptoms represent early sepsis, and they include fever, chills, and change in mental status. Other signs and symptoms include ... 

Other signs and symptoms to monitor for in a lesion, in addition to ABCDE, include ... 

Pheochromocytoma A tumor arising from chromaffin cells, most commonly found in the adrenal medulla. The tumor causes the adrenal medulla to hypersecrete epinephrine and norepinephrine, resulting in hypertension and other signs and symptoms of excessive sympathetic nervous system activity. The tumor is usually benign but may occasionally be cancerous. 

Other signs and symptoms associated with initial exposure include dizziness, nausea, palpitations, and decreases in systolic, diastolic, and pulse pressures. These initial signs and... 

Overdose of stimulants may lead to signs and symptoms of sympathetic overstimulation, including tremors, hypertension, fever, tachycardia, hyperreflexia, confusion, agitation, and frank psychosis or delirium. Management typically involves supportive measures to treat fever, severe hypertension, seizures, agitation, and other signs and symptoms. 

Hyperkalemia May occur in up to 26% of patients receiving spironolactone, even when combined with thiazide diuretics. Irregular heartbeat is usually the earliest clinical indication of hyperkalemia, and is readily detected by ECG. Other signs and symptoms include confusion, nervousness, numbness or tingling in extremities (hands, feet, or lips), shortness of breath or difficult breathing, unusual tiredness or weakness, or weakness or heaviness of legs. 

Timolol use can bring on wheezing, dyspnea, bronchospasm, and other signs and symptoms of decreased respiratory function. Acute bronchospasm can occm in previously asymptomatic asthmatic patients after the topical use of timolol.Timolol elicits an average decrease of 25% in forced expiratory volume (FEVl) in patients with chronic obstructive pulmonary disease (COPD) (Figure 107). 

The toxic effects of illicit fentanyl derivatives include rapid onset respiratory and central nervous system depression. Patients often present comatose and apneic. Other signs and symptoms consistent with opioid intoxication such as bradycardia, hypotension, miosis, and decreased gastrointestinal motility also occur. 

Documented cases of human poisoning by ricin aerosol exposure are unknown. Cautious inferences may be drawn from observations of NHP exposed to ricin under controlled laboratory settings. Human toxicity from ricin inhalation would be expected to occur after a latency period of 24—72 h that may be characterized by loss of appetite and listlessness. Based on extrapolation from NHP studies, other signs and symptoms expected in humans after ricin inhalation may include listlessness, high fever, dyspnea, and coughing or bloody sputum that is delayed for 4—8 h after exposure, as well as bilateral abnormalities on chest radiographs, arterial hypoxemia, neutrophilic leukocytosis, and elevated protein levels in bronchial aspirates (Balint, 1974 Wilhelmsen and Pitt, 1996 Franz and Jaax, 1997). 

Timely recognition of drug indications and other signs and symptoms relevant to drug use with accurate identification of underlying... 

Other signs and symptoms include irritability, delirium, drowsiness, lethargy, and coma. 

With appropriate wound care and antimicrobial therapy, infected pressure sores can heal. A reduction in erythema, warmth, pain, and other signs and symptoms should be seen in 48 to 72 hours. 

For early stage sores which are red, swollen, and painful and accompanied by other signs and symptoms of exterior patterns, add Flos Lonicerae Japonicae Yin Hua) and Fructus Forsythiae Suspensae Lian Qiao). This results in Yin Qiao Bai Du San (Lonicera Forsythia Vanquishing Toxins Powder). If there is no obvious vacuity, subtract Ginseng. 

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