Osteoprogenitor cells

Goodman SB, Ma T, Chin R, Ramachandran R, Smith RL. Effects of wear particles on osteoprogenitor cells. Biomaterials 2006 27 6096-6101. 

The skeleton is the body s principal reservoir of calcium and phosphorus. Contrary to its appearance, bone is a dynamic tissue, and calcium and phosphate are continuously deposited and released. Bone is a modified connective tissue consisting of a cellular component, an organic matrix and an inorganic (mineral) phase. Its cells are osteoblasts, osteoclasts, osteocytes, and osteoprogenitor cells. The last are a type of mesenchymal cell that can differentiate into any of the other three types and to which the other types can revert. 

Parathyroid hormone stimulates bone resorption by several mechanisms 1) Transformation of osteoprogenitor cells into osteoclasts is stimulated in the presence of PTH, 2) PTH promotes the deep osteocytes to mobilize calcium from perilacunar bone, and 3) surface osteocytes are stimulated by PTH to increase the flow of calcium out of the bone. 

In vitro studies by Bumgardner et al. showed that, after only 15 min, the number of cells from a human osteoprogenitor cell line on chitosan-coated titanium was eightfold higher than on the control titanium surface [39]. This increase in cell attachment was attributed in part to the increased attachment or adsorption of... 

Fig. 8 Attachment of human osteoprogenitor cells to chitosan films (77-92% DDA) in DMEM balanced salt solution as compared to DMEM balanced salt solution supplemented with 10% fetal bovine serum...

PLLA, PDLLA, Poly(ethylene glycol)(PEG)-PLLA, PEG-PDLLA Nonwoven scaffold TE Contact angles measurement, SEM, in vitro osteoprogenitor cell culture, alkaline phosphatase activity (Badami et al. 2006)... 

Osteoconductive Capable of supporting in-growth of sprouting capillaries, perivascular mesenchymal tissues, and osteoprogenitor cells from the recipient host into the three dimensional structure of a graft that act as a scaffold. 

Guillotin, B., Bourget, C., Remy-Zolgadri, M., BareUle, R., Fernandez, P., Conrad, V., Amedee-Vilamitjana, J. Human primary endothelial cells stimulate human osteoprogenitor cell differentiation. Cell. Physiol. Biochem. 14, 325-332... 

Villars, F., Guillotin, B., Amedee, T., Dutoya, S., Boidenave, L., BareUle, R., Amedee, J. Effect of HUVEC on human osteoprogenitor cell differentiation needs heterotypic gap junction communication. Am. J. Physiol. Cell Physiol. 282, C775-C785 (2002)... 

Bone, like other connective tissue in the embryo, is derived from mesenchymal cells. These cells have the ability to proliferate and differentiate into bone cells, which are known as osteoprogenitor cells. They are also called bone-precursor cells. 

Ko C-L, et al. Characterization of the aspects of osteoprogenitor cell interactions with physical tetracalcium phosphate anchorage on titanium implant surfaces. Mater Sci Eng C Mater Biol Appl 2015 49 7-13. 

Green, D., Howard, D., Yang, X., Kelly, M., Oreffo, R.O., 2003. Natural marine sponge fiber skeleton a biomimetic scaffold for human osteoprogenitor cell attachment, growth, and differentiation. Tissue Eng. 9, 1159—1166. 

Dong, J., Uemura, T, Shirasaki, Y., and Tateishi, T. Promotion of bone formation using highly pure porous beta-TCP combined with bone marrow-derived osteoprogenitor cells. Biomaterials 23 4493-4502, 2002. 

Schliephake, H., Knebel, J.W., Aufderheide, M., and Tauscher, M. Use of cultivated osteoprogenitor cells to increase bone formation in segmental mandibular defects an experimental pilot study in sheep. Int. J. Oral Maxillofac. Surg. 30 531-537,2001. 

Kruyt, M.C. et al, Bone tissue engineering and spinal fusion the potential of hybrid constructs by combining osteoprogenitor cells and scaffolds. Biomaterials 25,1463,2004. 

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