Osteoporosis goals

The primary goal of osteoporosis management is prevention. Optimizing skeletal development and peak bone mass accrual in childhood, adolescence, and early adulthood will reduce the future incidence of osteoporosis. 

Optimal management of the postmenopausal patient requires careful assessment of her symptoms as well as consideration of her age and the presence of (or risks for) cardiovascular disease, osteoporosis, breast cancer, and endometrial cancer. Bearing in mind the effects of the gonadal hormones on each of these disorders, the goals of therapy can then be defined and the risks of therapy assessed and discussed with the patient. 

One of the goals of synthetic medicinal chemistry is to design potent inilibitors of clinically important proteases. Elastase inhibitors may be useful for treatment of emphysema, pancreatitis, and arthritis,a/b while inhibitors of the angiotensinogen-converting enzyme or of renin (Box 22-D) can help control blood pressure. Inhibition of thrombin, factor Xa, or other blood clotting factors (Fig. 12-17) may prevent blood clots and inhibition of the cytosolic tryptase may provide a new treatment for asthma. Inhibition of the cysteine protease cathepsin K may help combat osteoporosis and inhibition of cysteine proteases of corona viruses may fight the common cold. Cysteine proteases of schistosomes are also targets for protease inhibitors.c... 

Furthermore, Pharma companies have not yet been very successful in treating the symptoms or in slowing the progression of many major diseases such as Alzheimer disease or osteoporosis. That being said, the slowing of disease progression can hardly be called an actual improvement, and it should not be the final goal of medical treatment. Best would... 

The goal from birth to around 20 to 30 years of age is to achieve the highest peak bone mass as possible. Beyond this age, the goals are to maintain BMD and minimize age-related and postmenopausal bone loss. In women and men with osteopenia, prevention of osteoporosis is the goal. For a variety of reasons, osteoporosis prevention is not always possible. For those at significant risk of developing an osteoporosis-related fracture, the aims are to increase bone mineral density, prevent further bone loss, and to prevent falls and fractures and their associated sequelae. For those who experience an osteoporosis-related fracture, the goals are to achieve adequate pain control, maximize rehahihtation... 

The goal of CNS prophylaxis is to eradicate undetectable leukemic cells from the CNS. Leukemic meningitis is more easily prevented than treated. Once CNS relapse has occnrred, patients are at increased risk of bone marrow relapse and death from refractory leukemia. Initial trials in childhood ALL in the 1960s established craniospinal irradiation as the standard for prevention of CNS relapse." However, this approach was associated with long-term seqnelae including neuropsychological deficits, precocious puberty, osteoporosis, thyroid dysfunction, an increased incidence of brain tumors, short stature, and obesity. Subseqnent trials have demonstrated that irradiation may be replaced by freqnent administration of intrathecal chemotherapy in most children with ALL."... 

Prevention, rather than cure, is the current goal. This should start in childhood with a good diet and exercise. The most powerful prediclorof osteoporosis is the skeletal mass at 16 years of age. 

The elderly female client diagnosed with osteoporosis is prescribed risedronate (Actonel), a bone resorption inhibitor. Wliich statement best describes the therapeutic goal of this therapy ... 

The goals of osteoporosis treatment are to control pain from the disease, reduce bone loss, and prevent bone fractures with medicines or hormone therapies. There are several types of treatments for osteoporosis including most famous bisphosphonates, estrogen agonists/antagonists, parathyroid... 

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