Orthologs

Frizzled (Fz) proteins comprise a family of seven-pass transmembrane receptors with a cysteine-rich extracellular domain. As a class, Fz proteins are structurally related to the superfamily ofheterotrimeric G-protein coupled receptors (GPCRs). Diere are 4 Fz genes in Drosophila and 10 in humans, with close orthologs... 

Shaker-channels, eag (ether- -go-go)-channels, slo (slow-poke)-channels were cloned from behavioral Drosophila melanogaster mutants. The channels were named according to the Drosophila mutant phenotype, Shaker, ether-go-go, slow-poke. Subsequently, eag-cDNA was used to clone related voltage-gated potassium channel subunits erg (eag-related) and elk (eag-like). The human erg ortholog (HERG) mediates cardiac DCS. 

There are 7 related Wnt genes in Drosophila and 19 in humans that generally have close orthologs in mice (Fig. 1). Orthologous Wnt gene-products are often very highly conserved between species. 

Dunstan C-AN, Salafranca MN, Adhikari S, Xia Y, Feng L, Harrison JK. Identification of two rat genes orthologous to the human interleukin-8 receptors. J Biol Chem 1996 271 32770-32776. 

Note Mammalian orthologs for the avian a8 and y4 subunits have not yet been identified. The p 1-3 subunit constitutes the GABAC receptors. 

Sakudoh, T., Tsuchida, K., and Kataoka, H. 2005. BmStartl, a novel carotenoid-binding protein isoform from Bombyx mori, is orthologous to MLN64, a mammalian cholesterol transporter. Biochem. Biophys. Res. Commun., 336(4) 1125—1135. 

Crawford, I. P. and Milkman R. (1991), Orthologous and paralogous divergence, reticulate evolution, and lateral gene transfer in bacterial trp genes , in R. K. Selander, A. G. Clark and... 

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