Sequence orthologous

Key Words Promoter sequences orthologous promoters conserved motifs motif search transcription regulation. 

Gene-gene relation Sequence similarity/orthology Positional correlation in genome Expression similarity (coregulation of genes)... 

Protein-protein relation Sequence similarity/orthology Enzyme-enzyme relation by successive reactions Transcription factor-transcribed gene product relation Direct protein-protein interaction... 

Of these, 11 function with ubiquitin and one with each of two different ubiquitin-like (UbL) proteins. Sumo and Nedd8/Rubl [2]. However, while several yeast and metazoan E3s had been identified biochemically by that time, the primary amino acid sequence was known only for a single E3 [7]. This was the Saccharomyces cer-evisiae Ubrlp, which had been studied extensively by Varshavsky and co-workers in delineation of the N-end rule [8, 9]. Its mammalian ortholog, E3a, was the prototypical E3 used in the description of the basics of the ubiquitin pathway by Hershko and Ciechanover [1, 10]. 

Fig. 7.8. Analysis of the Skpl-binding site of Cull and its comparison with other cullins indicate that other cullins all have a proteinbinding site at their NTD tip. Left, sequence alignment of orthologs of individual cullins, showing ortholog-restricted conservation of...

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