Orodispersible films

The results are comparable to the results of orodispersible films manufactured with the common solvent casting technique. In contrast, the active pharmaceutical ingredients are less stressed through mixing, solvent evaporation and heat. In addition, the loss of material due to cutting jumbo and daughter roUs can be reduced (76). 

It was shown that rasagiline mesylate reaystaUizes on the surface of orodispersible films and transparency films, and the printed crystals are arranged in lines. No drug crystals were detected after printing on the surface of the copy paper due to the absorption of the ink into the matrix of the substrate. 

E.M. Hoffmann, A. Breitenbach, J. Breitkreutz, Advances in orodispersible films for drug delivery. Expert Opin. DrugDeliv., 8 (3) 299-316, 2011. 

Chewable tablets are considered to be safe for use in children with full dentition (2-3 years) (76-78) and under supervision. Orodispersible preparations in the oral cavity (e.g., tablets, films, wafers) stand also on the periphery of solids and liquids, with the extra challenge that the quantity of excipients available to improve the palatability is limited. 

The applicability of the different model substrates, i.e., orodispersible fflms, porous copy paper sheets, and water impermeable transparency films, for the preparation of inkjet printed drug delivery systems was tested (77). An ordinary thermal inkjet printer was used. 

Risperidone free base preparations include film-coated tablets (1, 2, 3, 4 and 6 mg), orodispersible tablets (0.5, 1, 2, 3 and 4 mg), liquids at 1 mg/mL and depot preparations. Paliperidone is available as free base tablets (3, 6 and 9 mg), the hexadecanoate (palmitate) and extended release formulation using an osmotic-controlled release oral delivery system. 

Sertindole free base appears as film-coated tablets (4, 12, 16, 20 mg) but is less commonly prescribed due to the occurrence of cardiac arrhythmias and prolongation of the QT intervals. Aripiprazole is available in a variety of preparations such as tablets (5, 10, 15 and 30 mg), orodispersible tablets (10 and 15 mg), oral solutions (1 mg/mL) and injectables (7.5 mg/mL). 

Clozapine (Fig. 18.49), a dibenzodiazepine, is used as tablets (25 and 100 mg) and appears as the free base. Olanzapine (Fig. 18.49) appears in a number of formulations including film-coated tablets (2.5-20 mg) and orodispersible tablets (5-20 mg). It can also be used as a powder for reconstitution. Zotepine (Fig. 18.49) is available as free base sugar-coated tablets (25-100 mg). Quetiapine (Fig. 18.49), on the other hand, is prepared as the fiimarate salt and tablets range between 25 and 300 mg. 

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