Ornithine carbamoyl transferase

Sheep Once (GO) Hepatic 500M (elevated sorbital and glutamate dehydrogenases ornithine carbamoyl transferase decreased bromosulphthalein excretion) Fowler 1969b... 

Several lines of investigation assert to the inability of canal ine to function as an effective ornithine antagonist. Ornithine interaction with canaline has been evaluated with the ornithine carbamoyl transferase (EC 2.1.3.3) of human liver. Neither canal ine nor ornithine inhibited this enzyme when the other member of this set served as the carbamoyl group recipient (29). The ornithine antagonist, 2,4-diaminobutyric acid drastically reduced urea production in the rat this reflected curtailment of the ornithine carbamoyl transferase-mediated conversion of ornithine to citrulline. Yet, canaline had no such effect on urea formation in this mammal (30). 

Canaline is a potent inhibitor of all seven pyridoxal phosphate-containing enzymes studied by Rahiala et (27) but it lacks adverse effects on three ornithine-utiTTzing enzymes lacking a Bg cofactor. Finally, in jack bean, Canavalia ensiformis, ornithine carbamoyl transferase can form 0-ureido-L-homoserine from canaline and carbamoyl phosphate as it does citrulline from ornithine and carbamoyl phosphate. Nevertheless, neither compound inhibited formation of the reaction products (31). 

Carbamoyl phosphate synthetase Ornithine carbamoyl transferase Argininosuccinate synthetase 0 Argininosuccinate lyase Arginase... 

Brohult J. Effects of high protein and low protein diets on ornithine carbamoyl transferase activity in human serum (S-OCT). Acta Med Scand 1969 185 357-62. 

R8. Reichard, H., Ornithine carbamoyl transferase activity in human tissue homogenates. J. Lab. Clin. Med. 66, 218-221 (1960). 

Inborn errors of the six enzymes of ureagenesis and NAG synthase have been described. The inheritance pattern of the last is not known, but five of the urea cycle defects are autosomal recessive and ornithine carbamoyl-transferase (OCT) deficiency is X-linked. 

Two of the urea cycle enzymes (Figures 3.2.and 3.5), which are located in the hepato-cytes and both ornithine carbamoyl transferase (OCT) and arginase can provide evidence of liver damage in animals, although more data are available for OCT (Cornelius... 

Urea cycle Ornithine carbamoyl transferase Arginosuccinate synthetase Arginosuccinase Arginase Carbamoyl phosphate synthase... 

Figure 2.8. The urea cycle. CS = carbamoyl phosphate synthetase. OCT = ornithine carbamoyl transferase.. 45S = arginosuccinate synthetase. AS arginosuccinate. A = arginase...

D.R. Webster, H.A. Simmonds, D.M.J. Barry and D.M.O. Becroft. Pyrimidine and Purine Metabolites in Ornithine Carbamoyl Transferase Deficiency. 

Bachmann C. Ornithine carbamoyl transferase deficiency findings, models and problems. / Inherit Metab Dis 1992 15(4) 578-591... 

Arranz JA, Riudor E, Rodes M, et al. Optimization of allopurinol challenge sample purification, protein intake control, and the use of orotidine response as a discriminative variable improve performance of the test for diagnosing ornithine carbamoyl-transferase deficiency. Clinical Chemistry 1999 45(7) 995-1001... 

The agmatine pathway is similar to the arginine deiminase pathway (ADI), which is comprised of three reactions catalyzed by arginine deiminase, ornithine carbamoyl-transferase, and CK. The ADI pathway is widely distributed among LAB and has been described in strains from the Enterococcus, Lactobacillus, Lactococcus, Leuconostoc, Oenococcus, Streptococcus, and Weissella genera. 

Ryall, J.C., M.A. Quantz, andG.C. Shore, 1986. Rat-fiver and intestinal-mucosa differ in the developmental pattern and hormonal-regulation of carbamoyl-phosphate syrrthetase-i and ornithine carbamoyl transferase gene-expression. Eur. J. Biochem. 156, 453-458. 

Properties of Ornithine Carbamoyl Transferase from Plants and Other Sources... 

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