Arginosuccinate synthetase

Citrullinemia Unclear Urea cycle Arginosuccinate synthetase... 

Nussler, A. K., Billiar, T. R., Liu, Z. Z., and Morris, S. M. (1994). Coinduction of nitric oxide synthase and arginosuccinate synthetase in a murine macrophage cell line. /. Biol. Chem. 269, 1257-1261. 

Urea cycle Ornithine carbamoyl transferase Arginosuccinate synthetase Arginosuccinase Arginase Carbamoyl phosphate synthase... 

Figure 2.8. The urea cycle. CS = carbamoyl phosphate synthetase. OCT = ornithine carbamoyl transferase.. 45S = arginosuccinate synthetase. AS arginosuccinate. A = arginase...

Urea cycle disorders Hepatocytes Ornithine transcarbamylase or arginosuccinate synthetase... 

Acquired Immune Deficiency Syndrome Aldehyde Dehydrogenase Gene Cytosolic Aldehyde Dehydrogenase Alkaliphilic Bacteria Ampicillin Resistance Arginosuccinate Synthetase Autonomously Replicating Sequence Adenosine Triphosphate Gold... 

A number of inherited disorders of urea cycle metabolism are known. Hy per-ammonemia I and II are associated with CPS I and ornithine transcarbamylase deficiencies, respectively. Citrullinemia, arginosuccinic aciduria, and argininemia are associated with low levels of arginosuccinic acid synthetase, arginosuccinase, and arginase, respectively. All such disorders are associated with mental retardation, convulsions, and failure to thrive if not treated. Treatment involves the feeding of low-protein diets or, experimentally, the administration of a-keto analogs of essential amino acids instead of protein. 

Liver biopsies have revealed three different groups of patients those with low ornithine carbamyl transferase levels and hyperammonemia, those with low arginosuccinic acid synthetase and citrullinemia, and those with low argininosuccininase and argininosuc-cinicaciduria [62]. 

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