H+/peptide cotransporter

Ogihara, H., et al. Immuno-localization of H+/peptide cotransporter in rat digestive tract. Biochem. Biophys. Res. Commun. 1996, 220, 848-852. 

Liang, R., et al. Human intestinal H+/peptide cotransporter. Cloning, functional expression, and... 

Liu, W., et al. Molecular cloning of PEPT 2, a new member of the H+/ peptide cotransporter family, from human kidney. Biochim. Biophys. Acta 1995, 1235, 461-466. 

Saito, H., et al. Cloning and characterization of a rat H+/peptide cotransporter mediating absorption of beta-lactam antibiotics in the intestine and... 

Hsu, C. P., et al. Function and immunolocalization of overexpressed human intestinal H+/peptide cotransporter in adenovirus-transduced Caco-2 cells. AAPS PharmSci. 1999,... 

Terada, T., et al. Identification of the histidine residues involved in substrate recognition by a rat H+/ peptide cotransporter, PEPT1. FEES Lett. 1996, 394, 196-200. 

Liang R, Fei YJ, Prasad PD, Rama-moorthy S, Han H, Yang-Feng TL et al. Human intestinal H+/peptide cotransporter. Cloning, functional expression, and chromosomal localization. J Biol Chem 1995 270( 12) 6456-6463. 

Biegel, A., Gebauer, S., Brandsch, M., Neubert, K. and Thondorf I. (2006) Structural requirements for the substrates of the H+/peptide cotransporter PEPT2 determined by three-dimensional quantitative structure-activity relationship analysis. Journal of Medicinal Chemistry, 49, 4286-4296. 

Takahashi K, Nakamura N, Terada T, et al. Interaction of beta-lactam antibiotics with H+/peptide cotransporters in rat renal bmsh-border membranes. J Pharmacol Exp Ther 1998 286 1037-1042. 

H +/peptide cotransporter PEPT1. Journal of Medicinal Chemistry, 46 (26), 5725-5734. 

Bomer, V., Fei, Y.J., Hartrodt, B., Ganapathy, V., Leibach, F.H., Neubert, K. and Brandsch, M. (1998) Transport of amino acid aryl amides by the intestinal H + /peptide cotransport system, PEPT1. European Journal of Biochemistry, 255 (3), 698-702. 

Brandsch, M., Ganapathy, V. and Leibach, F.H. (1995) H( + )-peptide cotransport in Madin-Darby canine kidney cells expression and calmodulin-dependent regulation. The American Journal of Physiology, 268, F391-F397. 

Transport of many compounds including drugs across cell membranes is mediated by membrane proteins called carrier proteins or channel proteins. Some of these proteins transport only one substrate molecule at a time across the membrane (uniport systems), while others act as cotransport systems (Figure 9.4). Depending on the direction of the second substrate, the proteins are also called symporters or antiporters, for example, Na /glucose cotransporter, H " /peptide cotransporter, or Na /K antiporter (—Na /K -ATPase). 

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